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Ligand luciferyl-adenylate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 1 H2 0 N7 O9 PS2
luciferyl-adenylate
DVLIEEOCYVGZDS-RIWZETFMSA-N
D-luciferyl-AMP, luciferyl-AMP, luciferyl adenylate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (5 results)
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luciferyl-adenylate + O2 = oxyluciferin + AMP + CO2 + hv
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luciferyl-adenylate = oxyluciferin + hnu
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luciferyl-AMP + O2 = oxyluciferin + hv + CO2 + AMP + diphosphate
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D-luciferyl-AMP + O2 = dehydroluciferyl-AMP + H2O2
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luciferyl adenylate + O2 = dehydroluciferyl adenylate + ?
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Product in Enzyme-catalyzed Reactions (5 results)
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D-luciferin + ATP + O2 = luciferyl-adenylate
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D-luciferin + ATP + O2 = luciferyl-adenylate + diphosphate
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D-luciferin + ATP + O2 = luciferyl-adenylate + diphosphate + H2O + hv
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D-luciferin + ATP = diphosphate + luciferyl-adenylate
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D-luciferin + ATP + O2 = luciferyl-AMP + diphosphate
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Enzyme Kinetic Parameters
References & Links Literature References (5)
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Firefly luciferase produces hydrogen peroxide as a coproduct in dehydroluciferyl adenylate formation
2006
Fraga, H.; Fernandes, D.; Novotny, J.; Fontes, R.; Esteves da Silva, J.C.
Chembiochem
7
929-935
Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector
2005
Fraga, H.; Fernandes, D.; Fontes, R.; Esteves da Silva, J.C.
FEBS J.
272
5206-5216
Effect of charge distribution in a flexible loop on the bioluminescence color of firefly luciferases
2009
Moradi, A.; Hosseinkhani, S.; Naderi-Manesh, H.; Sadeghizadeh, M.; Alipour, B.S.
Biochemistry
48
575-582
Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions
2010
Inouye, S.
Cell. Mol. Life Sci.
67
387-404
False positives in a reporter gene assay: identification and synthesis of substituted N-pyridin-2-ylbenzamides as competitive inhibitors of firefly luciferase
2008
Heitman, L.H.; van Veldhoven, J.P.; Zweemer, A.M.; Ye, K.; Brussee, J.; IJzerman, A.P.
J. Med. Chem.
51
4724-4729
Links to other databases for luciferyl-adenylate
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