Ligand citrulline

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Basic Ligand Information

Molecular Structure
Picture of citrulline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13N3O3
citrulline
RHGKLRLOHDJJDR-UHFFFAOYSA-N
Synonyms:
2-amino-5-carbamidopentanoate, DL-citrulline

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine + NADPH + H+ + O2 = citrulline + nitric oxide + NADP+ + H2O
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carbamoyl phosphate + L-ornithine = phosphate + citrulline
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L-Arg + H2O = citrulline + NH3
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-L-glutamyl-4-nitroanilide + citrulline = 4-nitroaniline + 5-L-glutamyl-citrulline
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citrulline + H2O = ? + ?
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citrulline + H2O = ornithine + CO2 + NH3
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Product in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbamoyl phosphate + L-ornithine = phosphate + citrulline
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carbamoyl phosphate + ornithine = phosphate + citrulline
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citrulline-4-methylcoumaryl-7-amide + H2O = citrulline + 7-amino-4-methylcoumarin
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L-Arg + H2O = citrulline + NH3
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L-Arg + H2O = citrulline + NH3
show the reaction diagram

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to carbamoyl phosphate

3D Structure of Enzyme-Ligand-Complex (PDB) (19 results)

Enzyme Kinetic Parameters

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for citrulline

ChEBI
PubChem
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PubChem