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Ligand UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.92

UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate = UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine + 2-oxoglutarate

692984, 715485

-

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

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Show Natural Product (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.115

2 UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + 2 H2O

0

-

4.2.1.115

UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O

0

-

4.2.1.115

UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O

0

-

4.2.1.115

UDP-GlcNAc = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose + H2O

0

-

4.2.1.115

4 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.367

UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + NADPH + H+ = UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP+ + H+

727843, 725364, 726905

-

2.6.1.92

UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate = UDP-4-amino-4,6-dideoxy-L-N-acetyl-beta-L-altrosamine + 2-oxoglutarate

692984, 715485

-

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.115

2 UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + 2 H2O

0

-

4.2.1.115

UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O

0

-

4.2.1.115

UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O

0

-

4.2.1.115

UDP-GlcNAc = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose + H2O

0

-

4.2.1.115

4 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.6.1.92

0.067

-

pH 7.7, 37°C

692984

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.6.1.92

0.052

-

pH 7.7, 37°C

692984

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

692984

16286454

Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways

2006

Schoenhofen, I.C.; McNally, D.J.; Vinogradov, E.; Whitfield, D.; Young, N.M.; Dick, S.; Wakarchuk, W.W.; Brisson, J.R.; Logan, S.M.

J. Biol. Chem.

281

723-732

715485

16421095

Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori

2006

Schoenhofen, I.C.; Lunin, V.V.; Julien, J.P.; Li, Y.; Ajamian, E.; Matte, A.; Cygler, M.; Brisson, J.R.; Aubry, A.; Logan, S.M.; Bhatia, S.; Wakarchuk, W.W.; Young, N.M.

J. Biol. Chem.

281

8907-8916

725364

15778500

Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11

2005

Mulrooney, E.F.; Poon, K.K.; McNally, D.J.; Brisson, J.R.; Lam, J.S.

J. Biol. Chem.

280

19535-19542

726905

22320426

Crystal structure of the enzyme CapF of Staphylococcus aureus reveals a unique architecture composed of two functional domains

2012

Miyafusa, T.; Caaveiro, J.M.; Tanaka, Y.; Tsumoto, K.

Biochem. J.

443

671-680

727843

12464616

Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5: Implications for the UDP-N-acetyl-L-fucosamine

2003

Kneidinger, B.; ORiordan, K.; Li, J.; Brisson, J.; Lee, J.; Lam, J.

J. Biol. Chem.

278

3615-3627

Links to other databases for UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose

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Show Links (1 entry)

ChEBI

PubChem