Ligand L-ethionine

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Basic Ligand Information

Molecular Structure
Picture of L-ethionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13NO2S
L-ethionine
GGLZPLKKBSSKCX-YFKPBYRVSA-N
Synonyms:
(2S)-2-amino-4-(ethylsulfanyl)butanoic acid, S-ethyl-L-homocysteine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-ethionine + H2O + NAD+ = 4-ethylthio-2-oxobutanoate + NH3 + NADH
show the reaction diagram
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5-deoxy-5-chloroadenosine + S-ethyl-L-homocysteine = ?
show the reaction diagram
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2-oxosuccinamic acid + L-ethionine = L-asparagine + 4-ethylsulfanyl-2-oxobutanoate
show the reaction diagram
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L-ethionine + 2-oxoglutarate = 4-ethylsulfanyl-2-oxobutanoate + L-glutamate
show the reaction diagram
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L-Ethionine = 3-Ethylthiopropanamine + CO2
show the reaction diagram
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L-Ethionine = D-Ethionine
show the reaction diagram
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L-Ethionine = D-Ethionine
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-ethionine + L-homocysteine = S-adenosyl-L-homocysteine + L-ethionine
show the reaction diagram
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O-succinyl-L-homoserine + 2-mercaptoethanol = S-ethyl-L-homocysteine + succinate
show the reaction diagram
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O-acetyl-L-homoserine + ethyl mercaptan = L-ethionine + acetic acid
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N-acetyl-L-ethionine + H2O = acetate + L-ethionine
show the reaction diagram
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N-formyl-DL-ethionine + H2O = L-ethionine + CO2
show the reaction diagram
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D-ethionine = L-ethionine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enhances the activity of isozyme prolidase I
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Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition of anaerobic enzyme, 48% at 5 mM
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selective inhibitor of uracil tRNA methylase, non-competitive to S-adenosyl-L-methionine
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (15 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (27 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
35
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References & Links

Links to other databases for L-ethionine

ChEBI
PubChem
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PubChem