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Ligand 5beta-cholestan-3alpha,7alpha-diol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.139

5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O

686253, 688559, 688997, 689757, 688776

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Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.139

5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 = 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O

686253, 688559, 688997, 688776, 689757

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Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

686253

18473750

Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis

2008

Lundell, K.; Wikvall, K.

Curr. Drug Metab.

9

323-331

688559

17585019

Human and murine hepatic sterol-12-alpha-hydroxylase and other xenobiotic metabolism mRNA are upregulated by soy isoflavones

2007

Li, Y.; Mezei, O.; Shay, N.F.

J. Nutr.

137

1705-1712

688776

17696930

Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis

2007

Zollner, G.; Wagner, M.; Fickert, P.; Silbert, D.; Gumhold, J.; Zatloukal, K.; Denk, H.; Trauner, M.

Liver Int.

27

920-929

688997

18323469

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis

2008

Lee, Y.K.; Schmidt, D.R.; Cummins, C.L.; Choi, M.; Peng, L.; Zhang, Y.; Goodwin, B.; Hammer, R.E.; Mangelsdorf, D.J.; Kliewer, S.A.

Mol. Endocrinol.

22

1345-1356

689757

17895379

Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis

2007

Sanyal, S.; Bavner, A.; Haroniti, A.; Nilsson, L.M.; Lundasen, T.; Rehnmark, S.; Witt, M.R.; Einarsson, C.; Talianidis, I.; Gustafsson, J.A.; Treuter, E.

Proc. Natl. Acad. Sci. USA

104

15665-15670

Links to other databases for 5beta-cholestan-3alpha,7alpha-diol

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Show Links (1 entry)

ChEBI

PubChem

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