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BRENDA support

Ligand propylamine

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Basic Ligand Information

Molecular Structure
Picture of propylamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H9N
propylamine
WGYKZJWCGVVSQN-UHFFFAOYSA-N
Synonyms:
1-aminopropane, Aminopropane, n-Propylamine, propan-1-amine, propanamine, propyl-1-amine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
propan-1-amine + FADH2 + O2 = N-(propyl)hydroxylamine + FAD + H2O
show the reaction diagram
-
n-propylamine + NAD+ + H2O = propanal + NH3 + NADH + H+
show the reaction diagram
-
n-propylamine + H2O + O2 = propionaldehyde + NH3 + H2O2
show the reaction diagram
-
propylamine + acceptor + H2O = propionaldehyde + NH3 + reduced acceptor
show the reaction diagram
-
1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane + propylamine = ?
show the reaction diagram
-
pyruvate + propylamine = L-alanine + propanal
show the reaction diagram
-
benzoyl-Phe 4-guanidinephenyl ester + propylamine = 4-guanidinephenol + benzoyl-Phe-propylamide
show the reaction diagram
-
mesaconate + propanamine = ?
show the reaction diagram
-
ATP + L-Glu + n-propylamine = ADP + phosphate + N-propyl-L-glutamine
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dipropylamine + NADH + H+ + O2 = propylamine + acetaldehyde + NAD+ + H2O
show the reaction diagram
-
propionaldehyde + NH3 + NADH + H+ = n-propylamine + NAD+ + H2O
show the reaction diagram
-
fructosyl propylamine + O2 + H2O = glucosone + propylamine + H2O2
show the reaction diagram
-
methylpropylamine + H2O + acceptor = propylamine + formaldehyde + reduced acceptor
show the reaction diagram
-
taurine + propanal = 2-sulfoacetaldehyde + propyl-1-amine
show the reaction diagram
-
propanal + (S)-1-phenylethylamine = propylamine + acetophenone
show the reaction diagram
-
N-(n-propyl)sulfamate + H2O = n-propylamine + sulfate
show the reaction diagram
-
N4-ethyl-L-asparagine = L-Asp + propylamine
show the reaction diagram
-
N-propylcaproamide + H2O = propylamine + hexanoate
show the reaction diagram
-
N5-n-propyl-L-glutamine + H2O = L-glutamate + n-propylamine
show the reaction diagram
-
n-propylguanidine + H2O = n-propylamine + urea
show the reaction diagram
-
L-2-Aminobutanoate = n-Propylamine + CO2
show the reaction diagram
-
4-aminobutanoate = propylamine + CO2
show the reaction diagram
-
L-gamma-glutamyl-n-propylamine = n-propylamine + 5-oxo-L-proline
show the reaction diagram
-
5-L-glutamyl-n-propylamine = 5-oxoproline + propylamine
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation of enzyme from K176A mutant
-
alphaH44A mutant, works as catalytic base
-
5 mM, relative activity 121%
-
slight activation of mutant K202A
-

Inhibitor in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
-
-
inhibition of wild-type enzyme
-
500 mM, 87% inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (39 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
132
-
-
0.0004
-
1-N-(carbobenzoxy-L-glutaminylglycyl)-5-N-(5'-N',N'-dimethylamino-1'-naphthalenesulfonyl)diamidopentane as glutamine donor

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.059
-
at pH 7.0 and 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.62
-
-
4
10
substrate 4-nitrophenyl-beta-D-xylopyranoside, 25°C, pH 7.0

References & Links

Links to other databases for propylamine

ChEBI
PubChem
ChEBI
PubChem