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Ligand oroxylin A

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.81

2-nitrophenyl-beta-D-glucopyranoside + oroxylin A = 2-nitrophenol + 5-hydroxy-6-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranoside

759388

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2.4.1.81

UDP-glucose + oroxylin A = UDP + ?

759388

-

2.4.1.81

2 entries

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.167

5,7-dihydroxy-6-methoxyflavone-7-O-beta-D-glucuronate + H2O = 5,7-dihydroxy-6-methoxyflavone + D-glucuronate

0

-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

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Show Inhibitors (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.1

-

750021

-

3.2.1.20

from hexane extracts of the Indian herb Oroxylum indicum

678697

-

3.3.2.10

75.88% inhibition

753858

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3.4.21.26

0.1 mM, 20% enzyme inhibition

708539

-

4.4.1.5

140% inhibition of rhGLO I at 0.1 mM

691217

-

Enzyme Kinetic Parameters

IC₅₀ Value (4 results)

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Show IC50 Value (4 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.1.1.1

0.02082

-

pH 7.4, 37°C

750021

3.2.1.20

0.124

-

-

678697

3.2.1.20

0.135

-

-

678697

3.2.1.20

2 entries

3.3.2.10

0.04482

-

pH not specified in the publication, 37°C

753858

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

678697

18255289

Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors

2008

Hari Babu, T.; Rama Subba Rao, V.; Tiwari, A.K.; Suresh Babu, K.; Srinivas, P.V.; Ali, A.Z.; Madhusudana Rao, J.

Bioorg. Med. Chem. Lett.

18

1659-1662

691217

18258440

Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects

2008

Takasawa, R.; Takahashi, S.; Saeki, K.; Sunaga, S.; Yoshimori, A.; Tanuma, S.

Bioorg. Med. Chem.

16

3969-3975

708539

20117183

Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers

2010

Marques, M.R.; Stueker, C.; Kichik, N.; Tarrago, T.; Giralt, E.; Morel, A.F.; Dalcol, I.I.

Fitoterapia

81

552-6

750021

29421708

Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2

2018

Weng, Z.M.; Ge, G.B.; Dou, T.Y.; Wang, P.; Liu, P.K.; Tian, X.H.; Qiao, N.; Yu, Y.; Zou, L.W.; Zhou, Q.; Zhang, W.D.; Hou, J.

Bioorg. Chem.

77

320-329

753858

30980876

Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition kinetics and interaction mechanism merged with simulations

2019

Liu, Z.B.; Sun, C.P.; Xu, J.X.; Morisseau, C.; Hammock, B.D.; Qiu, F.

Int. J. Biol. Macromol.

133

1187-1193

759388

30821967

Identification and characterization of two new 1-O-acyl-glucose-ester forming glucosyltransferases from Erigeron breviscapus

2019

Yang, Y.; Liu, M.; Zhang, W.; Cao, Y.; Li, C.; Wang, W.

J. Agric. Food Chem.

67

2848-2855

Links to other databases for oroxylin A

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Show Links (1 entry)

ChEBI

PubChem