Ligand P1,P4-bis(5'-adenosyl) tetraphosphate

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Basic Ligand Information

Molecular Structure
Picture of P1,P4-bis(5'-adenosyl) tetraphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H28N10O19P4
P1,P4-bis(5'-adenosyl) tetraphosphate
YOAHKNVSNCMZGQ-XPWFQUROSA-N
Synonyms:
5',5''-diadenosine tetraphosphate, 5',5'-diadenosine tetraphosphate, A(5')p4(5')A, adenosine (5')-tetraphospho-(5')-adenosine, adenosine(5')tetraphospho(5')adenosine, adenosine-5'-tetraphospho-5'-adenosine, adenosine 5'-P1-tetraphospho-P4-5'''-adenosine, diadenosine 5',5''''-P1,P4-tetraphosphate, diadenosine 5',5''',P1,P4-tetraphosphate, diadenosine 5',5'''-P1,P4-tetraphosphate, diadenosine 5',5'',P1,P4-tetraphosphate, diadenosine 5',5''-P1, P4-tetraphosphate, diadenosine 5',5''-P1,P4-tetraphosphate, diadenosine 5',5'-tetraphosphate, P1,P4-bis(5'-adenosyl)tetraphosphate, P1,P4-bis(adenosine-5')tetraphosphate, P1,P4-bis(adenosyl)tetraphosphate, P1,P4-di(adenosine-5') tetraphosphate, P1,P4-di(adenosine-5')tetraphosphate, P1,P4-diadenosine 5'-tetraphosphate, P1,P4-diadenosine tetraphosphate, P1-(5'-adenosyl) P3-(5'-adenosyl)tetraphosphate
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for P1,P4-bis(5'-adenosyl) tetraphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate = ?
show the reaction diagram
3 diadenosine 5',5''-P1,P4-tetraphosphate + 3 H2O = 2 ATP + 2 ADP + 2 AMP
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 ATP = diadenosine 5',5'''-P1,P4-tetraphosphate + diphosphate
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylallyl diphosphate + P1,P4-bis(5'-adenosyl)tetraphosphate = ?
show the reaction diagram
-
ATP + adenosine(5')tetraphospho(5')adenosine = diphosphate + ?
show the reaction diagram
-
adenosine 5'-P1-tetraphospho-P4-5'''-adenosine + H2O = AMP + ATP
show the reaction diagram
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = ?
show the reaction diagram
-
adenosine (5')-tetraphospho-(5')-adenosine + H2O = ?
show the reaction diagram
-
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP
show the reaction diagram
-
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP
show the reaction diagram
-
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
luciferin + ATP + O2 = diadenosine 5',5''-P1,P4-tetraphosphate
show the reaction diagram
-
ADP + ATP = P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
show the reaction diagram
adenosine 5'-phosphoimidazolide + ATP = imidazole + A(5')p4(5')A
show the reaction diagram
-
-
MgATP2- = diadenosine 5',5'',P1,P4-tetraphosphate + ?
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulation at low concentrations, inhibition above 0.3 mM
-

Inhibitor in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
not di-, tri- or pentaphosphate derivative
-
i.e. AP4A, inhibits in the presence of AMP
-
i.e. AP4A, inhibits in the presence of AMP
-
ADP/phosphate-exchange

3D Structure of Enzyme-Ligand-Complex (PDB) (20 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (27 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.1
-
pH 9.0, 37C
16.9
-
pH 8.0, 37C, presence of 5 mM Mg2+, 1 mM dithiothreitol

KM Value (49 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.07
-
pH 9.0, 37C
0.2
-
-
0.0218
-
pH 8.0, 37C, presence of 5 mM Mg2+, 1 mM dithiothreitol

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID

References & Links

Links to other databases for P1,P4-bis(5'-adenosyl) tetraphosphate

ChEBI
PubChem
ChEBI
PubChem