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Ligand [L-Asp(4-L-Arg)]n-L-Asp

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.30

ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-Arg = ADP + phosphate + [L-Asp(4-L-Arg)]n+1

701820, 662783, 690533, 690592, 691115, 726759, 728700, 726784, 661623, 662187

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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.29

[L-Asp(4-L-Arg)]n + L-Asp + ATP = [L-Asp(4-L-Arg)]n-Asp + ADP + phosphate

0

-

6.3.2.29

ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp

0

-

6.3.2.29

2 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.30

ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-Arg = ADP + phosphate + [L-Asp(4-L-Arg)]n+1

701820, 662783, 690533, 690592, 660741, 691115, 726759, 728700, 726784, 661623, 661619, 660829, 662187, 660739, 661970

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6.3.2.30

ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-Arg = [L-Asp(4-L-Arg)]n+1 + ADP + phosphate

671478

-

6.3.2.30

2 entries

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.29

[L-Asp(4-L-Arg)]n + L-Asp + ATP = [L-Asp(4-L-Arg)]n-Asp + ADP + phosphate

0

-

6.3.2.29

ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp

0

-

6.3.2.29

ATP + [L-Asp(4-L-Arg)]n + L-Asp = [L-Asp(4-L-Arg)]n-L-Asp + ADP + phosphate

0

-

6.3.2.29

3 entries

Enzyme Kinetic Parameters

References & Links

Literature References (16)

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Show Reference (16 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

660739

11319097

Purification of Synechocystis sp. strain PCC6308 cyanophycin synthetase and its characterization with respect to substrate and primer specificity

2001

Aboulmagd, E.; Oppermann-Sanio, F.B.; Steinbüchel, A.

Appl. Environ. Microbiol.

67

2176-2182

660741

11772614

Molecular characterization of a thermostable cyanophycin synthetase from the thermophilic cyanobacterium Synechococcus sp. strain MA19 and in vitro synthesis of cyanophycin and related polyamides

2002

Hai, T.; Oppermann-Sanio, F.B.; Steinbüchel, A.

Appl. Environ. Microbiol.

68

93-101

660829

11131019

Molecular characterization of the cyanophycin synthetase from Synechocystis sp. strain PCC6308

2000

Aboulmagd, E.; Oppermann-Sanio, F.B.; Steinbüchel, A.

Arch. Microbiol.

174

297-306

661619

9652408

Molecular characterization of cyanophycin synthetase, the enzyme catalyzing the biosynthesis of the cyanobacterial reserve material multi-L-poly-L-aspartate (cyanophycin)

1998

Ziegler, K.; Diener, A.; Herpin, C.; Richter, R.; Deutzmann, R.; Lockau, W.

Eur. J. Biochem.

254

154-159

661623

10951215

Biosynthesis of the cyanobacterial reserve polymer multi-L-arginyl-poly-L-aspartic acid (cyanophycin)

2000

Berg, H.; Ziegler, K.; Piotukh, K.; Baier, K.; Lockau, W.; Volkmer-Engert, R.

Eur. J. Biochem.

267

5561-5570

661970

6767688

Cyanophycin granule polypeptide formation and degradation in the cyanobacterium Aphanocapsa 6308

1980

Allen, M.M.; Hutchison, F.; Weathers, P.J.

J. Bacteriol.

141

687-693

662187

14679189

Nitrogen-regulated genes for the metabolism of cyanophycin, a bacterial nitrogen reserve polymer

2004

Picossi, S.; Valadares, A.; Flores, E.; Herrero, A.

J. Biol. Chem.

279

11582-11592

662783

15289556

Partial purification and characterization of a non-cyanobacterial cyanophycin synthetase from Acinetobacter calcoaceticus strain ADP1 with regard to substrate specificity, substrate affinity and binding to cyanophycin

2004

Krehenbrink, M.; Steinbüchel, A.

Microbiology

150

2599-2608

671478

17012590

Engineered cyanophycin synthetase (CphA) from Nostoc ellipsosporum confers enhanced CphA activity and cyanophycin accumulation to Escherichia coli

2006

Hai, T.; Frey, K.M.; Steinbuechel, A.

Appl. Environ. Microbiol.

72

7652-7660

690533

18408064

Synthesis and accumulation of cyanophycin in transgenic strains of Saccharomyces cerevisiae

2008

Steinle, A.; Oppermann-Sanio, F.B.; Reichelt, R.; Steinbuechel, A.

Appl. Environ. Microbiol.

74

3410-3418

690592

18679674

A cyanophycin synthetase from Thermosynechococcus elongatus BP-1 catalyzes primer-independent cyanophycin synthesis

2008

Arai, T.; Kino, K.

Appl. Microbiol. Biotechnol.

81

69-78

691115

18977318

The role of the C-terminal region of cyanophycin synthetase from Nostoc ellipsosporum NE1 in its enzymatic activity and thermostability: A key function of Glu(856)

2008

Hai, T.; Lee, J.S.; Kim, T.J.; Suh, J.W.

Biochim. Biophys. Acta

1794

42-49

701820

20038708

Establishment of cyanophycin biosynthesis in Pichia pastoris and optimization by use of engineered cyanophycin synthetases

2010

Steinle, A.; Witthoff, S.; Krause, J.P.; Steinbuechel, A.

Appl. Environ. Microbiol.

76

1062-1070

726759

21972133

Production of cyanophycin in Rhizopus oryzae through the expression of a cyanophycin synthetase encoding gene

2012

Meussen, B.J.; Weusthuis, R.A.; Sanders, J.P.; Graaff, L.H.

Appl. Microbiol. Biotechnol.

93

1167-1174

726784

23579730

Isolation and characterization of a novel cyanophycin synthetase from a deep-sea sediment metagenomic library

2013

Du, J.; Li, L.; Ding, X.; Hu, H.; Lu, Y.; Zhou, S.

Appl. Microbiol. Biotechnol.

97

8619-8628

728700

24550502

Compartmentalized cyanophycin metabolism in the diazotrophic filaments of a heterocyst-forming cyanobacterium

2014

Burnat, M.; Herrero, A.; Flores, E.

Proc. Natl. Acad. Sci. USA

111

3823-3828

Links to other databases for [L-Asp(4-L-Arg)]n-L-Asp

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Show Links (1 entry)

ChEBI

PubChem

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