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BRENDA support

Ligand ethylene glycol

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Basic Ligand Information

Molecular Structure
Picture of ethylene glycol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H6O2
ethylene glycol
LYCAIKOWRPUZTN-UHFFFAOYSA-N
Synonyms:
1,2-ethandiol, 1,2-ethanediol, ethandiol, ethane-1,1-diol, ethane-1,2-diol, ethanediol, ethylene glycoI, ethyleneglycol, ethylenglycol, glycol, hydroxyethanol


Show all pahtways known for Show all BRENDA pathways known for ethylene glycol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-ethanediol + O2 = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycolaldehyde + NADH + H+ = ethylene glycol + NAD+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (122 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-ethanediol + NADP+ = hydroxyacetaldehyde + NADPH
show the reaction diagram
-
ethylene glycol + NAD+ = NADH + ?
show the reaction diagram
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ethane-1,2-diol + NAD+ = glyoxal + NADH
show the reaction diagram
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ethanediol + NADP+ = glyoxal + NADPH
show the reaction diagram
-
ethane-1,1-diol + NADP+ = ? + NADPH
show the reaction diagram
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ethylene glycol + NAD+ = glycolaldehyde + NADH + H+
show the reaction diagram
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ethyleneglycol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
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1,2-ethanediol + ferricyanide = hydroxyacetaldehyde + ferrocyanide
show the reaction diagram
-
adenosine 5'-triphosphate + ethylene glycol = adenosine 5'-monophosphate-O-ethylene glycolyl ester + H2O + diphosphate
show the reaction diagram
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phosphatidylcholine + ethyleneglycol = phosphatidylethyleneglycol + choline
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (43 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycolaldehyde + NADH + H+ = ethylene glycol + NAD+
show the reaction diagram
-
-
glycolaldehyde + NADPH = ethyleneglycol + NADP+
show the reaction diagram
-
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glyoxal + NADPH = glycol + NADP+
show the reaction diagram
glycolaldehyde + NADH + H+ = ethane-1,2-diol + NAD+
show the reaction diagram
-
2-Hydroxyethyl-phosphate + H2O = Hydroxyethanol + phosphate
show the reaction diagram
-
glycolaldehyde hydrate = ethandiol
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (240 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
addition of ethylene glycol at 33 vol% to the reaction medium for cephalexin synthesis improves the yield from 70% to 95%
-
activation
-
20% increase of activity at 10% ethylene glycol
-
60%, 300fold stimulation
-
4-8%, 50% activation
-

Inhibitor in Enzyme-catalyzed Reactions (102 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition, IC50 4 mM
-
inhibitory to hydrogen production
-
10% (v/v), 60% inhibition
-
mixed-type reversible inhibitor, 21.9% inhibition at 1 mM
noncompetitive with sucrose and phosphate
-
80% inhibition at 20% v/v
-
28% inhibition at 10% (vol/vol)
-
1% (v/v), about 15% loss of activity, 5% (v/v), about 30% loss of activity
34% inhibition at 1%
-
80% inhibition at 50%; 80% inhibition at 50% ethylene glycol
-
weak
-
inactivates the EAL holoenzyme
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3D Structure of Enzyme-Ligand-Complex (PDB) (74687 results)

EC NUMBER
ENZYME 3D STRUCTURE