Ligand ethylene glycol

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Basic Ligand Information

Molecular Structure
Picture of ethylene glycol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H6O2
ethylene glycol
MBHXKZDTQCSVPM-NKEGIDLKSA-N
Synonyms:
1,2-ethandiol, 1,2-ethanediol, ethandiol, ethane-1,1-diol, ethane-1,2-diol, ethanediol, ethylene glycoI, ethyleneglycol, ethylenglycol, glycol, hydroxyethanol


Show all pahtways known for Show all BRENDA pathways known for ethylene glycol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-ethanediol + O2 = ?
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Substrate in Enzyme-catalyzed Reactions (118 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-ethanediol + NADP+ = hydroxyacetaldehyde + NADPH
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ethylene glycol + NAD+ = NADH + ?
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ethane-1,2-diol + NAD+ = glyoxal + NADH
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ethanediol + NADP+ = glyoxal + NADPH
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ethane-1,1-diol + NADP+ = ? + NADPH
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ethylene glycol + NAD+ = glycolaldehyde + NAD+
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ethyleneglycol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
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1,2-ethanediol + ferricyanide = hydroxyacetaldehyde + ferrocyanide
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adenosine 5'-triphosphate + ethylene glycol = adenosine 5'-monophosphate-O-ethylene glycolyl ester + H2O + diphosphate
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phosphatidylcholine + ethyleneglycol = phosphatidylethyleneglycol + choline
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Product in Enzyme-catalyzed Reactions (39 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glycolaldehyde + NADPH = ethyleneglycol + NADP+
show the reaction diagram
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glyoxal + NADPH = glycol + NADP+
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glycolaldehyde + NADH + H+ = ethane-1,2-diol + NAD+
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bis(2-hydroxyethyl) terephthalic acid + H2O = mono(2-hydroxyethyl)terephthalic acid + ethylene glycol
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2-Hydroxyethyl-phosphate + H2O = Hydroxyethanol + phosphate
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glycolaldehyde hydrate = ethandiol
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Activator in Enzyme-catalyzed Reactions (184 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
addition of ethylene glycol at 33 vol% to the reaction medium for cephalexin synthesis improves the yield from 70% to 95%
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activation
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20% increase of activity at 10% ethylene glycol
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60%, 300fold stimulation
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4-8%, 50% activation
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Inhibitor in Enzyme-catalyzed Reactions (92 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition, IC50 4 mM
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inhibitory to hydrogen production
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10% (v/v), 60% inhibition
-
mixed-type reversible inhibitor, 21.9% inhibition at 1 mM
noncompetitive with sucrose and phosphate
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80% inhibition at 20% v/v
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cleavage product accumulation decreases the activity of cutinase during PET hydrolysis
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28% inhibition at 10% (vol/vol)
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1% (v/v), about 15% loss of activity, 5% (v/v), about 30% loss of activity
34% inhibition at 1%
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80% inhibition at 50%; 80% inhibition at 50% ethylene glycol
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weak
-
inactivates the EAL holoenzyme
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inhibits by reducing electron flow between cytochrome a and cytochrome a3

3D Structure of Enzyme-Ligand-Complex (PDB) (66015 results)

EC NUMBER
ENZYME 3D STRUCTURE