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Ligand (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C4 8 H8 0 N7 O2 0 P3 S
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
MNYDLIUNNOCPHG-FJWDCHQMSA-N
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA, (25R)-trihydroxycoprostanoyl-CoA, (R)-trihydroxycoprostanoyl-CoA, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA, trihydroxycoprostanoyl-CoA
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
trihydroxycoprostanoyl-CoA + H2O = trihydroxycoprostanate + CoA
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA = AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
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Substrate in Enzyme-catalyzed Reactions (7 results)
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trihydroxycoprostanoyl-CoA + H2O + acceptor = 3alpha,7alpha,12alpha,24-tetrahydroxycoprostanoyl-CoA + reduced acceptor
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trihydroxycoprostanoyl-CoA + O2 = ?
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trihydroxycoprostanoyl-CoA + H2O = CoA + trihydroxycoprostanoate
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trihydroxycoprostanoyl-CoA + H2O = CoA + trihydroxycoprostanoate
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trihydroxycoprostanoyl-CoA + H2O = trihydroxycoprostanate + CoA
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3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA = ?
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(25R)-trihydroxycoprostanoyl-CoA = (25S)-trihydroxycoprostanoyl-CoA
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Product in Enzyme-catalyzed Reactions (3 results)
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(S)-Trihydroxycoprostanoyl-CoA = (R)-Trihydroxycoprostanoyl-CoA
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(25S)-trihydroxycoprostanoyl-CoA = (25R)-trihydroxycoprostanoyl-CoA
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ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA = AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
KM Value (3 results)
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References & Links Literature References (10)
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Subcellular localization of 3alpha,7alpha-dihydroxy- and 3alpha,7alpha,12alpha-trihydroxy-5beta-cholastanoyl-coenzyme A ligase(s) in rat liver
1988
Prydz, K.; Kase, B.F.; Bjoerkhem, I.; Pedersen, J.I.
J. Lipid Res.
29
997-1004
Purification and properties of an alpha-methylacyl-CoA racemase from rat liver
1994
Schmitz, W.; Fingerhut, R.; Conzelmann, E.
Eur. J. Biochem.
222
313-323
Purification and characterization of an alpha-methylacyl-CoA racemase from human liver
1995
Schmitz, W.; Albers, C.; Fingerhut, R.; Conzelmann, E.
Eur. J. Biochem.
231
815-822
Inhibition of peroxisomal fatty acyl-CoA oxidase by antimycin A
1987
Vamecq, J.; Schepers, L.; Parmentier, G.; Mannaerts, G.P.
Biochem. J.
248
603-607
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism
2002
Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.
J. Biol. Chem.
277
1128-1138
Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation
1993
Östlund, A.K.; Nilsson, A.; Pedersen, J.I.
J. Lipid Res.
34
2041-2050
Purification and further characterization of peroxisomal trihydroxycoprostanoyl-CoA oxidase from rat liver
1994
van Veldhoven, P.P.; van Rompuy, P.; Vanhooren, J.C.; Mannaerts, G.P.
Biochem. J.
304
195-200
Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase
1996
van Veldhoven, P.P.; Croes, K.; Asselberghs, S.; Herdewijn, P.; Mannaerts, G.P.
FEBS Lett.
388
80-84
A continuous assay for alpha-methylacyl-coenzyme A racemase using circular dichroism
2010
Ouazia, D.; Bearne, S.L.
Anal. Biochem.
398
45-51
Inhibition of human alpha-methylacyl CoA racemase (AMACR): A target for prostate cancer
2013
Carnell, A.; Kirk, R.; Smith, M.; Mckenna, S.; Lian, L.; Gibson, R.
ChemMedChem
8
1643-1647
Links to other databases for (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA
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