Ligand 5-iodo-UMP
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Basic Ligand Information
C9H12IN2O9P
5-iodo-UMP
HXJLWCWPONZYNP-TZLAVLDLSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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5-iodo-UMP + diphosphate = 5-iodouracil + 5-phospho-alpha-D-ribose 1-diphosphate
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Product in Enzyme-catalyzed Reactions (1 result)
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5-iodouracil + 5-phospho-alpha-D-ribose 1-diphosphate = 5-iodo-UMP + diphosphate
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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Enzyme Kinetic Parameters
IC50 Value (1 result)
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References & Links
Literature References (4)
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Regulatory mechanisms differ in UMP kinases from Gram-negative and Gram-positive bacteria
2007
Evrin, C.; Straut, M.; Slavova-Azmanova, N.; Bucurenci, N.; Onu, A.; Assairi, L.; Ionescu, M.; Palibroda, N.; Barzu, O.; Gilles, A.
J. Biol. Chem.
282
7242-7253
Structures of the human orotidine-5-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design
2008
Wittmann, J.G.; Heinrich, D.; Gasow, K.; Frey, A.; Diederichsen, U.; Rudolph, M.G.
Structure
16
82-92
Sustainable synthesis of uridine-5-monophosphate analogues by immobilized uracil phosphoribosyltransferase from Thermus thermophilus
2020
Del Arco, J.; Galindo, J.; Clemente-Suarez, V.J.; Corrales, A.; Fernandez-Lucas, J.
Biochim. Biophys. Acta
1868
140251
Sustainable synthesis of uridine-5-monophosphate analogues by immobilized uracil phosphoribosyltransferase from Thermus thermophilus
2020
Del Arco, J.; Galindo, J.; Clemente-Suarez, V.J.; Corrales, A.; Fernandez-Lucas, J.
Biochim. Biophys. Acta
1868
140251
Links to other databases for 5-iodo-UMP
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