Ligand dATP

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Basic Ligand Information

Molecular Structure
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Molecular Formula
BRENDA Name
InChIKey
C10H16N5O12P3
dATP
SUYVUBYJARFZHO-RRKCRQDMSA-N
Synonyms:
2'-dATP, 2'-deoxy-adenosine 5'-triphosphate, 2'-deoxy-ATP, 2'-deoxyadenosine-3'-triphosphate, 2'-deoxyadenosine 5'-triphosphate, 2'-deoxyATP, 2-dATP, 2-deoxyadenosine 5'-triphosphate, 2-DeoxyATP, 5'-dATP, Deoxy-ATP, deoxyadenosine 5'-triphosphate, deoxyATP


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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cob(I)alamin + dATP + H2O + H+ = deoxyadenosylcobalamin + diphosphate + phosphate
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dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate
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dATP + H2O = dADP + phosphate
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dATP + H2O = ?
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dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA
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dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dADP + (phosphate)n+1 = dATP + (phosphate)n
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Substrate in Enzyme-catalyzed Reactions (593 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R
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dATP + citrate + CoA = dADP + phosphate + acetyl-CoA + oxaloacetate
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dimethylallyl diphosphate + dATP = ?
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dimethylallyl diphosphate + dATP = diphosphate + N6-(dimethylallyl)dATP
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2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate
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dATP + 5-methylthioribose = dADP + 5-methylthioribose 1-phosphate
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2'-deoxy-ATP + sn-1,2-dihexanoylglycerol = 2'-deoxy-ADP + sn-1,2-dihexanoylglycerol 3-phosphate
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dATP + D-fructose 6-phosphate = dADP + D-fructose 1,6-bisphosphate
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dATP + D-ribose = dADP + D-ribose 5-phosphate
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dATP + adenosylcobinamide = adenosylcobinamide phosphate + dADP
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dATP + L-seryl-tRNASec = dADP + O-phospho-L-seryl-tRNASec
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dATP + 2-deoxy-D-ribose = dADP + 2-deoxy-D-ribose 5-phosphate
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dATP + adenosine 5-phosphosulfate = dADP + 3'-phosphoadenosine 5'-phosphosulfate
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dATP + mevalonate = dADP + phosphomevalonate
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dATP + D-fructose = dADP + D-fructose 6-phosphate
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dATP + D-glucuronate = dADP + 1-phospho-D-glucuronate
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dATP + 4-methyl-5-(2-hydroxyethyl)thiazole = dADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole
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dATP + N-acetyl-D-glucosamine = dADP + N-acetyl-D-glucosamine 6-phosphate
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dATP + glucose = dADP + D-glucose 6-phosphate
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2'-deoxy-ATP + scyllo-inosamine = 2'-deoxy-ADP + scyllo-inosamine phosphate
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dATP + D-mannose = dADP + D-mannose 6-phosphate
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2'-deoxyATP + shikimate = 2'-deoxyADP + shikimate 3-phosphate
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dATP + streptomycin = dADP + streptomycin 6-phosphate
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dATP + deoxycytidine = dADP + dCMP
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dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] = dADP + ?
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dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
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dATP + carbamate = dADP + carbamoyl phosphate
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dATP + N-acetyl-L-glutamate = dADP + N-acetyl-L-glutamate 5-phosphate
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2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate = 2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
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dATP + 5-methyldeoxycytidine 5'-phosphate = dADP + 5-methyldeoxycytidine diphosphate
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dATP + CMP = dADP + CDP
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dATP + dTMP = dADP + dTDP
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dATP + UMP = dADP + UDP
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dATP + D-ribose 5-phosphate = dAMP + 5-phospho-alpha-D-ribose 1-diphosphate
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dATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = dAMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
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dATP + GTP = dAMP + guanosine 3'-diphosphate 5'-triphosphate
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dATP + RNA = diphosphate + ?
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dATP + alpha-D-glucose 1-phosphate = dADP-glucose + diphosphate
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2'-deoxy-ATP + pantetheine 4'-phosphate = ?
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dATP + SO42- = diphosphate + deoxyadenylylsulfate
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dATP + RNAn = diphosphate + RNAn+1
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2'-deoxy-ATP + RNAn = diphosphate + RNAn+1
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p-tRNAHis + dATP + GTP = pppGp-tRNAHis + dAMP + diphosphate
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dATP + alpha-D-glucose 1-phosphate = diphosphate + dADP-alpha-D-glucose
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2'-dATP + pyruvate + phosphate = ?
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dATP + H2O = ?
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dATP + H2O = ?
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dATP + H2O = dITP + NH3
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dATP + H2O = dITP + NH3
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dATP + H2O = dADP + phosphate
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dATP + H2O = dADP + phosphate
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dATP + H2O = dAMP + diphosphate
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dATP + H2O = dADP + phosphate
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dATP + H2O = ?
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dATP + H2O = ?
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dATP + H2O = dAMP + diphosphate
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dATP + H2O = dADP + phosphate
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dATP + H2O = dAMP + diphosphate
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dATP + H2O = dAMP + diphosphate
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dATP + H2O = dAMP + diphosphate
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dATP + H2O = dAMP + diphosphate
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dATP + H2O = dAMP + diphosphate
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dATP + 5-diphosphomevalonate = dADP + phosphate + isopentenyl diphosphate + CO2
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dATP = deoxy-cAMP + diphosphate
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2'-dATP + H2O + a dynein associated with a microtubule at position n = 2'-dADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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2'-dATP + H2O + a kinesin associated with a microtubule at position n = 2'-dADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
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dATP + H2O + closed Cl- channel = dADP + phosphate + open Cl- channel
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dATP + negatively supercoiled circular DNA = dADP + phosphate + relaxed circular DNA
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2'-deoxyadenosine 5'-triphosphate + L-arginine + tRNAArg = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg
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2'-deoxyadenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe
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dATP + L-histidine + tRNAHis = dAMP + diphosphate + L-histidyl-tRNAHis
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2'-dATP + L-leucine + tRNALeu = 2'-dAMP + diphosphate + L-leucyl-tRNALeu
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dATP + lysine + tRNALys = dAMP + L-lysyl-tRNALys + diphosphate
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dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA
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dATP + a fatty acid + [acyl-carrier protein] = dAMP + diphosphate + fatty acid-[acyl-carrier protein]
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dATP + acetate + citrate (pro-3S)-lyase = dAMP + diphosphate + citrate(pro-3S)-lyase
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dATP + fatty acid + CoA = dAMP + diphosphate + acyl-CoA
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dATP + cholate + CoA = dAMP + diphosphate + choloyl-CoA
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dATP + deamido-NAD+ + NH3 = dAMP + diphosphate + NAD+
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dATP + 7,8-dihydropteroate + L-Glu = dADP + phosphate + 7,8-dihydrofolate
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dATP + gamma-Glu-L-Cys + Gly = dADP + phosphate + glutathione
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dATP + 5-formyltetrahydrofolate = dADP + phosphate + 5,10-methylenetetrahydrofolate
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deoxyATP + UTP + NH4+ = deoxyADP + phosphate + CTP
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dATP + formate + tetrahydrofolate = dADP + phosphate + 10-formyltetrahydrofolate
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dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate
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dATP + urea + HCO3- = ?
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dATP + acetyl-CoA + HCO3- = dADP + phosphate + malonyl-CoA
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dATP + (ribonucleotide)n + (ribonucleotide)m = dAMP + phosphate + (ribonucleotide)n+m
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dATP + hydrogenobyrinic acid a,c-diamide + Co2+ = dADP + phosphate + cob(II)yrinic acid a,c-diamide + H+
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dATP + H2O + H+/in = dADP + phosphate + H+/out
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2'-deoxyATP + H2O + H+/in + K+/out = 2'-deoxyADP + phosphate + H+/out + K+/in
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dATP + H2O = dADP + H2O
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + formate = dATP + CO2 + H2O
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1-methyl-dATP + 2-oxoglutarate + O2 = dATP + formaldehyde + succinate + CO2
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dADP + phosphoenolpyruvate = dATP + pyruvate
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dADP + phospholombricine = dATP + lombricine
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dADP + phosphoramide = dATP + NH3
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2'-dAMP + phosphoenolpyruvate + diphosphate = 2'-dATP + pyruvate + phosphate
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2'-deoxyadenosine adenosine tetraphosphate + H2O = ATP + 2'-dAMP + 2'-dATP + AMP
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dADP + phosphate + acetyl-CoA = dATP + acetate + CoA
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Enzyme Cofactor/Cosubstrate (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates
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activation, can replace ATP to some extent
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about 25% of the activity with ATP
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activation
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73% of the activity with ATP and deoxycytidine, 6% of the activity with ATP and deoxyadenosine
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best cofactor, Pcal_1127 exhibits slightly higher activity with dATP compared to ATP as diphosphate donor
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Activator in Enzyme-catalyzed Reactions (302 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
highly activating
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positive effector for CTP reduction
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nearly as effective as ATP
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both dATP and dGTP are co-activators for hydrolysis of dTTP, dATP might bind at the secondary allosteric site
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activates
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the enzyme's helicase activity requires ATP or dATP
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at least 2fold enhancement of enzyme activity, maximal at 20 microM, similar results with all four deoxynucleoside triphosphates
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poor allosteric activator
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Inhibitor in Enzyme-catalyzed Reactions (531 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
18% inhibition at 0.5 mM
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4% inhibition
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