Ligand dATP

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Basic Ligand Information

Molecular Structure

C₁₀H₁₆N₅O₁₂P₃

dATP

SUYVUBYJARFZHO-RRKCRQDMSA-N

Synonyms:

2'-dATP, 2'-deoxy-adenosine 5'-triphosphate, 2'-deoxy-ATP, 2'-deoxyadenosine-3'-triphosphate, 2'-deoxyadenosine 5'-triphosphate, 2'-deoxyATP, 2-dATP, 2-deoxyadenosine 5'-triphosphate, 2-DeoxyATP, 5'-dATP, Deoxy-ATP, deoxyadenosine 5'-triphosphate, deoxyATP

BRENDA

purine metabolism

KEGG

Purine metabolism

MetaCyc

adenosine deoxyribonucleotides de novo biosynthesis I, adenosine deoxyribonucleotides de novo biosynthesis II, purine deoxyribonucleosides salvage

Show all BRENDA pathways known for dATP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (12 results)

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2.5.1.17

cob(I)alamin + dATP + H2O + H+ = deoxyadenosylcobalamin + diphosphate + phosphate

674576

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

dATP + H2O = dADP + phosphate

684774, 757096, 696275

3.6.1.9

dATP + H2O = ?

246817

6.2.1.1

dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA

652101

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n

662058

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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2.7.4.1

dADP + (phosphate)n+1 = dATP + (phosphate)n

645125

Substrate in Enzyme-catalyzed Reactions (654 results)

peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R

659421

2.3.3.8

dATP + citrate + CoA = dADP + phosphate + acetyl-CoA + oxaloacetate

488211, 488225

2.5.1.112

dimethylallyl diphosphate + dATP = ?

dimethylallyl diphosphate + dATP = diphosphate + N6-(dimethylallyl)dATP

671796

2.5.1.6

2'-deoxy-ATP + L-methionine + H2O = ?

639047, 639045, 639049, 639056, 639041, 639052, 639039, 639042, 639043, 639044, 639053, 639054, 639058, 639051, 639055, 639057, 639038, 639040, 639048, 639074, 639046, 639050

2.6.99.1

2 entries

2.7.1.1

2'-dATP + D-glucose = 2'-dADP + D-glucose 6-phosphate

640226, 640209, 640208

2.7.1.100

dATP + 5-methylthioribose = dADP + 5-methylthioribose 1-phosphate

640268

2.7.1.107

2'-deoxy-ATP + sn-1,2-dihexanoylglycerol = 2'-deoxy-ADP + sn-1,2-dihexanoylglycerol 3-phosphate

640387

2.7.1.11

dATP + D-fructose 6-phosphate = dADP + D-fructose 1,6-bisphosphate

640421, 640463, 640486

2.7.1.113

2 entries

2.7.1.15

dATP + D-ribose = dADP + D-ribose 5-phosphate

641000

2.7.1.156

dATP + adenosylcobinamide = adenosylcobinamide phosphate + dADP

644438

2.7.1.164

dATP + L-seryl-tRNASec = dADP + O-phospho-L-seryl-tRNASec

694429

2.7.1.229

dATP + 2-deoxy-D-ribose = dADP + 2-deoxy-D-ribose 5-phosphate

dATP + adenosine 5-phosphosulfate = dADP + 3'-phosphoadenosine 5'-phosphosulfate

dATP + mevalonate = dADP + phosphomevalonate

641436

2.7.1.4

dATP + D-fructose = dADP + D-fructose 6-phosphate

641483, 641497, 641507

2.7.1.43

dATP + D-glucuronate = dADP + 1-phospho-D-glucuronate

dATP + 4-methyl-5-(2-hydroxyethyl)thiazole = dADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole

639720, 737878

2.7.1.59

dATP + N-acetyl-D-glucosamine = dADP + N-acetyl-D-glucosamine 6-phosphate

dATP + glucose = dADP + D-glucose 6-phosphate

641750

2.7.1.65

2'-deoxy-ATP + scyllo-inosamine = 2'-deoxy-ADP + scyllo-inosamine phosphate

dATP + D-mannose = dADP + D-mannose 6-phosphate

641894

2.7.1.71

2'-deoxyATP + shikimate = 2'-deoxyADP + shikimate 3-phosphate

641904

2.7.1.72

dATP + streptomycin = dADP + streptomycin 6-phosphate

dATP + deoxycytidine = dADP + dCMP

dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] = dADP + ?

640979

2.7.11.31

dATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = dADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate

644956

2.7.2.2

dATP + carbamate = dADP + carbamoyl phosphate

dATP + N-acetyl-L-glutamate = dADP + N-acetyl-L-glutamate 5-phosphate

2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate = 2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate

645172

2.7.4.19

dATP + 5-methyldeoxycytidine 5'-phosphate = dADP + 5-methyldeoxycytidine diphosphate

642548

2.7.4.25

dATP + CMP = dADP + CDP

dATP + dTMP = dADP + dTDP

645196, 645201, 645203, 645188, 645189, 645191, 645193, 645198, 692915, 695005, 737398

2.7.4.B1

dATP + UMP = dADP + UDP

663751

2.7.6.1

dATP + D-ribose 5-phosphate = dAMP + 5-phospho-alpha-D-ribose 1-diphosphate

642710, 642712, 642729, 738194, 642738, 642716, 728136

2.7.6.3

dATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = dAMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

dATP + GTP = dAMP + guanosine 3'-diphosphate 5'-triphosphate

dATP + RNA = diphosphate + ?

2'-deoxy-ATP + pantetheine 4'-phosphate = ?

dATP + SO42- = diphosphate + deoxyadenylylsulfate

643261, 643292, 643281

2.7.7.46

2 entries

2.7.7.48

dATP + RNAn = diphosphate + RNAn+1

2'-deoxy-ATP + RNAn = diphosphate + RNAn+1

p-tRNAHis + dATP + GTP = pppGp-tRNAHis + dAMP + diphosphate

dATP + NAD+ = ?

dATP + alpha-D-glucose 1-phosphate = diphosphate + dADP-alpha-D-glucose

662454, 748158

2.7.9.1

2'-dATP + pyruvate + phosphate = ?

dATP + H2O = ?

dATP + H2O = ?

209371, 209380, 209381

3.5.4.17

dATP + H2O = dITP + NH3

246706

3.5.4.18

dATP + H2O = dITP + NH3

172176, 246717

3.6.1.1

dATP + H2O = dADP + phosphate

712033

3.6.1.10

dATP + H2O = dADP + phosphate

756125

3.6.1.12

dATP + H2O = dAMP + diphosphate

722230, 733297, 734816

3.6.1.15

dATP + H2O = dADP + phosphate

667694, 656494, 684774, 670074, 757096, 696275

dATP + H2O = ?

dATP + H2O = ?

dATP + H2O = dAMP + diphosphate

711327, 756316, 657286

3.6.1.5

3 entries

3.6.1.52

dATP + H2O = dADP + phosphate

393824

3.6.1.55

dATP + H2O = dAMP + diphosphate

756066

3.6.1.56

dATP + H2O = dAMP + diphosphate

757347

3.6.1.65

dATP + H2O = dAMP + diphosphate

756613

3.6.1.67

dATP + H2O = dAMP + diphosphate

728808

3.6.1.8

dATP + H2O = dAMP + diphosphate

dATP + 5-diphosphomevalonate = dADP + phosphate + isopentenyl diphosphate + CO2

4377

4.6.1.1

dATP = deoxy-cAMP + diphosphate

34793

5.6.1.2

2'-dATP + H2O + a dynein associated with a microtubule at position n = 2'-dADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)

210563, 247036

5.6.1.4

2'-dATP + H2O + a kinesin associated with a microtubule at position n = 2'-dADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)

210563

5.6.1.6

dATP + H2O + closed Cl- channel = dADP + phosphate + open Cl- channel

751114

5.6.2.2

dATP + negatively supercoiled circular DNA = dADP + phosphate + relaxed circular DNA

2'-deoxyadenosine 5'-triphosphate + L-arginine + tRNAArg = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg

273, 280

6.1.1.20

2'-deoxyadenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe

340, 347

6.1.1.21

dATP + L-histidine + tRNAHis = dAMP + diphosphate + L-histidyl-tRNAHis

372

6.1.1.4

2'-dATP + L-leucine + tRNALeu = 2'-dAMP + diphosphate + L-leucyl-tRNALeu

442

6.1.1.6

dATP + lysine + tRNALys = dAMP + L-lysyl-tRNALys + diphosphate

483

6.2.1.1

dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA

652101, 568, 563

6.2.1.20

dATP + a fatty acid + [acyl-carrier protein] = dAMP + diphosphate + fatty acid-[acyl-carrier protein]

689

6.2.1.22

dATP + acetate + citrate (pro-3S)-lyase = dAMP + diphosphate + citrate(pro-3S)-lyase

695

6.2.1.3

dATP + fatty acid + CoA = dAMP + diphosphate + acyl-CoA

758, 764, 759

6.2.1.7

dATP + cholate + CoA = dAMP + diphosphate + choloyl-CoA

843

6.3.1.5

dATP + deamido-NAD+ + NH3 = dAMP + diphosphate + NAD+

953

6.3.2.12

dATP + 7,8-dihydropteroate + L-Glu = dADP + phosphate + 7,8-dihydrofolate

dATP + gamma-Glu-L-Cys + Gly = dADP + phosphate + glutathione

1191, 1194

6.3.3.2

dATP + 5-formyltetrahydrofolate = dADP + phosphate + 5,10-methylenetetrahydrofolate

1322

6.3.4.2

deoxyATP + UTP + NH4+ = deoxyADP + phosphate + CTP

648982

6.3.4.3

dATP + formate + tetrahydrofolate = dADP + phosphate + 10-formyltetrahydrofolate

1506

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

1576

6.3.4.6

dATP + urea + HCO3- = ?

dATP + acetyl-CoA + HCO3- = dADP + phosphate + malonyl-CoA

dATP + (ribonucleotide)n + (ribonucleotide)m = dAMP + phosphate + (ribonucleotide)n+m

1985, 1984, 1997, 1995, 1910

6.6.1.2

dATP + hydrogenobyrinic acid a,c-diamide + Co2+ = dADP + phosphate + cob(II)yrinic acid a,c-diamide + H+

653078

7.1.2.1

dATP + H2O + H+/in = dADP + phosphate + H+/out

2'-deoxyATP + H2O + H+/in + K+/out = 2'-deoxyADP + phosphate + H+/out + K+/in

246853, 246851

7.6.2.1

dATP + H2O = dADP + H2O

246839, 246842

Product in Enzyme-catalyzed Reactions (15 results)

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1.1.98.6

ATP + formate = dATP + CO2 + H2O

1.14.11.33

1-methyl-dATP + 2-oxoglutarate + O2 = dATP + formaldehyde + succinate + CO2

1.17.4.2

3 entries

2.7.1.40

dADP + phosphoenolpyruvate = dATP + pyruvate

2.7.3.5

dADP + phospholombricine = dATP + lombricine

2.7.3.8

dADP + phosphoramide = dATP + NH3

2'-dAMP + phosphoenolpyruvate + diphosphate = 2'-dATP + pyruvate + phosphate

3.6.1.17

2'-deoxyadenosine adenosine tetraphosphate + H2O = ATP + 2'-dAMP + 2'-dATP + AMP

209914

6.2.1.13

dADP + phosphate + acetyl-CoA = dATP + acetate + CoA

Enzyme Cofactor/Cosubstrate (21 results)

stimulates

activation, can replace ATP to some extent

485955

2.5.1.17

about 25% of the activity with ATP

activation

73% of the activity with ATP and deoxycytidine, 6% of the activity with ATP and deoxyadenosine

642253, 642256, 642268, 642251, 642248, 642254

2.7.6.1

best cofactor, Pcal_1127 exhibits slightly higher activity with dATP compared to ATP as diphosphate donor

Activator in Enzyme-catalyzed Reactions (302 results)

highly activating

positive effector for CTP reduction

nearly as effective as ATP

both dATP and dGTP are co-activators for hydrolysis of dTTP, dATP might bind at the secondary allosteric site

activates

the enzyme's helicase activity requires ATP or dATP

757547

4.2.99.B1

at least 2fold enhancement of enzyme activity, maximal at 20 microM, similar results with all four deoxynucleoside triphosphates

692974

4.6.1.2

poor allosteric activator

Inhibitor in Enzyme-catalyzed Reactions (551 results)

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1.1.1.205

18% inhibition at 0.5 mM

4% inhibition