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Ligand phosphocholine

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

phosphatidylethanolamine bioynthesis

KEGG

Choline metabolism in cancer, Glycerophospholipid metabolism, Teichoic acid biosynthesis

MetaCyc

2-arachidonoylglycerol biosynthesis, cell-surface glycoconjugate-linked phosphocholine biosynthesis, choline biosynthesis I, choline biosynthesis III, phosphatidylcholine biosynthesis I, phosphatidylcholine biosynthesis II, phospholipases, plasmalogen biosynthesis I (aerobic), plasmalogen degradation, sphingolipid biosynthesis (mammals), sphingomyelin metabolism, type IV lipoteichoic acid biosynthesis (S. pneumoniae) more

Show all BRENDA pathways known for phosphocholine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.15

CTP + choline phosphate = diphosphate + CDP-choline

661238, 660981, 662320, 661213, 662237, 662364, 663437, 662689, 662451

4zcr, 3D-view

2.7.7.15

CTP + choline phosphate = diphosphate + CDPcholine

642913, 642893, 642891, 642922, 642925, 642916, 642908, 642909, 642901

4zcr, 3D-view

2.7.7.15

CTP + phosphocholine = diphosphate + CDP-choline

721712, 721989, 761981, 737438, 762177, 761489, 762404, 762463, 762455, 761500, 761872, 761501, 761598

4zcr, 3D-view

3.1.3.75

O-phosphocholine + H2O = choline + phosphate

664697, 664211

-

3.1.3.75

phosphocholine + H2O = choline + phosphate

713654, 714357, 714872, 714874, 714360, 715704, 654549

-

2.7.7.15

3 entries

3.1.3.75

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (28 results)

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Show Natural Product (28 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.32

ATP + choline = ADP + O-phosphocholine

0, 641368

2ckq, 3D-view

2.7.1.32

choline + ATP = O-phosphocholine + ADP

0

2ckq, 3D-view

2.7.1.32

ATP + choline = ADP + phosphocholine

0

2ckq, 3D-view

2.7.1.32

choline + ATP = phosphocholine + ADP

0

2ckq, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + choline phosphate

0

5i85, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + choline phosphate

0

5tcd, 3D-view

3.1.4.12

platelet-activating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate

0

5i85, 3D-view

3.1.4.12

platelet-activating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate

0

5tcd, 3D-view

3.1.4.12

platelet-inactivating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate + ?

0

5i85, 3D-view

3.1.4.12

platelet-inactivating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate + ?

0

5tcd, 3D-view

3.1.4.12

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

652079, 651148, 651338, 652444, 652543, 653119, 0, 650323, 651315, 652706, 653103, 653120, 652090, 652972, 650366, 650502, 650584, 651801, 652701, 649984, 649682, 649563, 652601, 652461, 653652, 652373, 652974, 651708

5i85, 3D-view

3.1.4.12

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

652079, 651148, 651338, 652444, 652543, 653119, 0, 650323, 651315, 652706, 653103, 653120, 652090, 652972, 650366, 650502, 650584, 651801, 652701, 649984, 649682, 649563, 652601, 652461, 653652, 652373, 652974, 651708

5tcd, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + phosphocholine

0

5i85, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + phosphocholine

0

5tcd, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphocholine

0

5i85, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphocholine

0

5tcd, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphorylcholine

0

5i85, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphorylcholine

0

5tcd, 3D-view

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + choline phosphate

0

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-sn-diacylglycerol + phosphocholine

0

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacylglycerol + phosphorylcholine

135280, 94309, 133931, 135299, 135308, 135293, 135303, 135306

-

3.1.4.3

sphingomyelin + H2O = ceramide + phosphorylcholine

135299, 135292

-

3.1.4.38

sn-glycero-3-phosphocholine + H2O = glycerol + phosphocholine

0

1wra, 3D-view

3.1.4.38

sn-glycero-3-phosphocholine + H2O = glycerol + phosphocholine

0

5egh, 3D-view

2.7.1.32

4 entries

3.1.4.12

14 entries

3.1.4.3

5 entries

3.1.4.38

2 entries

3.6.1.13

CDP-choline + H2O = CMP + phosphocholine

0

-

3.6.1.53

CDP-choline + H2O = CMP + phosphocholine

0

-

3.6.1.9

CDP-choline + H2O = CMP + phosphorylcholine

246812

-

Substrate in Enzyme-catalyzed Reactions (17 results)

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Show Substrate (17 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.B6

phosphorylcholine + O2 = ?

724736

-

1.14.11.72

phosphocholine + 2-oxoglutarate + O2 = glycine betaine aldehyde + phosphate + succinate + CO2

756059

-

2.7.7.14

CTP + phosphocholine = diphosphate + CDP-choline

642887

-

2.7.7.15

CTP + choline phosphate = diphosphate + CDP-choline

661238, 660981, 662320, 662451, 691071, 691467, 692989, 693012, 693101, 694149, 694082, 661213, 662237, 662364, 663437, 693089, 693144, 662689, 690911, 691047, 701930, 704587

4zcr, 3D-view

2.7.7.15

CTP + choline phosphate = diphosphate + CDPcholine

642911, 642921, 642928, 642892, 642902, 642910, 642920, 642889, 642890, 642893, 642894, 642895, 642896, 642898, 642900, 642903, 642904, 642905, 642906, 642907, 642908, 642909, 642913, 642914, 642915, 642916, 642919, 642923, 642924, 642926, 642918, 642891, 642925, 642917, 642899, 642901, 642897, 642912, 642922, 642927

4zcr, 3D-view

2.7.7.15

CTP + phosphocholine = diphosphate + CDP-choline

721712, 721989, 761981, 737438, 762177, 761489, 762404, 762463, 762455, 761500, 761872, 761501, 761598

4zcr, 3D-view

2.7.7.15

3 entries

2.7.7.57

CTP + choline phosphate = CDP-choline + diphosphate

485052

-

3.1.1.3

phosphocholine + H2O = ?

653521

-

3.1.3.1

phosphocholine + H2O = choline + phosphate

706940

-

3.1.3.1

phosphorylcholine + H2O = phosphate + choline

94613, 94607

-

3.1.3.2

choline O-phosphate + H2O = choline + phosphate

134702

-

3.1.3.2

phosphocholine + H2O = choline + phosphate

134726, 134741, 134752, 715966, 134804, 134754

-

3.1.3.2

phosphorylcholine + H2O = choline + phosphate

664921, 666338

-

3.1.3.75

O-phosphocholine + H2O = choline + phosphate

664697, 696420, 664211

-

3.1.3.75

phosphocholine + H2O = choline + phosphate

702538, 713654, 714357, 714872, 714874, 714360, 715704, 654549, 679380

-

3.1.6.6

phosphoryl choline + H2O = choline + phosphate

751335

-

3.1.6.6

phosphorylcholine + H2O = choline + phosphate

135665

-

3.1.3.1

2 entries

3.1.3.2

3 entries

3.1.3.75

2 entries

3.1.6.6

2 entries

Product in Enzyme-catalyzed Reactions (140 results)

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Show Product (140 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.103

N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = choline phosphate + S-adenosyl-L-homocysteine

0

5wp4, 3D-view

2.1.1.103

3 S-adenosyl-L-methionine + phosphoethanolamine = 3 S-adenosyl-L-homocysteine + phosphocholine

0

5wp4, 3D-view

2.1.1.103

S-adenosyl-L-methionine + N,N-dimethylethanolamine phosphate = S-adenosyl-L-homocysteine + phosphocholine

0

5wp4, 3D-view

2.1.1.103

S-adenosyl-L-methionine + phosphodimethylethanolamine = S-adenosyl-L-homocysteine + phosphocholine

485058, 485053, 485059, 485052, 485056, 485057, 485061, 0, 485062

5wp4, 3D-view

2.7.1.32

CTP + choline = CDP + choline phosphate

0

2ckq, 3D-view

2.7.1.32

GTP + choline = GDP + choline phosphate

0

2ckq, 3D-view

2.7.1.32

UTP + choline = UDP + choline phosphate

0

2ckq, 3D-view

2.7.1.32

ATP + choline = ADP + O-phosphocholine

641346, 0, 641351, 641368

2ckq, 3D-view

2.7.1.32

choline + ATP = O-phosphocholine + ADP

0

2ckq, 3D-view

2.7.1.32

ATP + choline = ADP + phosphocholine

0

2ckq, 3D-view

2.7.1.32

choline + ATP = phosphocholine + ADP

0

2ckq, 3D-view

2.7.1.32

choline + ATP = phosphorylcholine + ADP

0

2ckq, 3D-view

2.7.1.82

ATP + choline = ADP + choline phosphate

0

2ckq, 3D-view

2.7.1.82

choline + ATP = ADP + O-phosphocholine

0

2ckq, 3D-view

2.1.1.103

4 entries

2.7.1.32

8 entries

2.7.1.82

2 entries

3.1.3.2

p-nitrophenyl phosphorylcholine + H2O = p-nitrophenol + phosphorylcholine

0

-

3.1.4.1

4-nitrophenyl phosphocholine + H2O = 4-nitrophenol + phosphocholine

0

-

3.1.4.1

p-nitrophenylphosphorylcholine + H2O = p-nitrophenol + phosphorylcholine

0

-

3.1.4.12

1-alkyl-lyso-platelet activating factor + H2O = 1-alkylglycerol + choline phosphate

650323

5i85, 3D-view

3.1.4.12

1-alkyl-lyso-platelet activating factor + H2O = 1-alkylglycerol + choline phosphate

650323

5tcd, 3D-view

3.1.4.12

2-(N-hexadecanoylamino)-4-nitrophenylphosphorylcholine + H2O = 2-(N-hexadecanoylamino)-4-nitrophenol + choline phosphate

652444

5i85, 3D-view

3.1.4.12

2-(N-hexadecanoylamino)-4-nitrophenylphosphorylcholine + H2O = 2-(N-hexadecanoylamino)-4-nitrophenol + choline phosphate

652444

5tcd, 3D-view

3.1.4.12

2-hexadecanoylamino-4-nitrophenylphosphocholine + H2O = 2-hexadecanoylamino-4-nitrophenol + choline phosphate

650502, 651801

5i85, 3D-view

3.1.4.12

2-hexadecanoylamino-4-nitrophenylphosphocholine + H2O = 2-hexadecanoylamino-4-nitrophenol + choline phosphate

650502, 651801

5tcd, 3D-view

3.1.4.12

2-n-hexadecanoylamino-4-nitrophenylphosphorylcholine + H2O = 2-n-hexadecanoylamino-4-nitrophenol + choline phosphate

0

5i85, 3D-view

3.1.4.12

2-n-hexadecanoylamino-4-nitrophenylphosphorylcholine + H2O = 2-n-hexadecanoylamino-4-nitrophenol + choline phosphate

0

5tcd, 3D-view

3.1.4.12

4-nitrobenz-2-oxa-1,3-diazole-sphingosylphosphorylcholine + H2O = 4-nitrobenz-2-oxa-1,3-diazole-sphingosine + choline phosphate

651708

5i85, 3D-view

3.1.4.12

4-nitrobenz-2-oxa-1,3-diazole-sphingosylphosphorylcholine + H2O = 4-nitrobenz-2-oxa-1,3-diazole-sphingosine + choline phosphate

651708

5tcd, 3D-view

3.1.4.12

6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)sphingosyl phosphocholine + H2O = 6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino-N-hexanoylsphingosine + choline phosphate

0

5i85, 3D-view

3.1.4.12

6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-hexanoyl)sphingosyl phosphocholine + H2O = 6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino-N-hexanoylsphingosine + choline phosphate

0

5tcd, 3D-view

3.1.4.12

6-hexadecanoylamino-4-methylumbelliferyl-phosphocholine + H2O = 6-hexadecanoylamino-4-methylumbelliferone + choline phosphate

0

5i85, 3D-view

3.1.4.12

6-hexadecanoylamino-4-methylumbelliferyl-phosphocholine + H2O = 6-hexadecanoylamino-4-methylumbelliferone + choline phosphate

0

5tcd, 3D-view

3.1.4.12

6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O = 6-hexadecanoylamino-4-methylumbelliferone + choline phosphate

0

5i85, 3D-view

3.1.4.12

6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O = 6-hexadecanoylamino-4-methylumbelliferone + choline phosphate

0

5tcd, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + choline phosphate

0

5i85, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + choline phosphate

0

5tcd, 3D-view

3.1.4.12

hexadecanoyl-p-nitrophenylphosphorylcholine + H2O = hexadecanoyl-p-nitrophenol + choline phosphate

0

5i85, 3D-view

3.1.4.12

hexadecanoyl-p-nitrophenylphosphorylcholine + H2O = hexadecanoyl-p-nitrophenol + choline phosphate

0

5tcd, 3D-view

3.1.4.12

lyso-platelet-activating factor + H2O = 1-alkylglycerol + choline phosphate

651338

5i85, 3D-view

3.1.4.12

lyso-platelet-activating factor + H2O = 1-alkylglycerol + choline phosphate

651338

5tcd, 3D-view

3.1.4.12

lyso-platelet-activating factor + H2O = alkylglycerol + choline phosphate

651338

5i85, 3D-view

3.1.4.12

lyso-platelet-activating factor + H2O = alkylglycerol + choline phosphate

651338

5tcd, 3D-view

3.1.4.12

lysophosphatidylcholine + H2O = 1-acylglycerol + choline phosphate

0, 135166

5i85, 3D-view

3.1.4.12

lysophosphatidylcholine + H2O = 1-acylglycerol + choline phosphate

0, 135166

5tcd, 3D-view

3.1.4.12

lysophosphatidylcholine + H2O = acylglycerol + choline phosphate

651801, 651338, 651708

5i85, 3D-view

3.1.4.12

lysophosphatidylcholine + H2O = acylglycerol + choline phosphate

651801, 651338, 651708

5tcd, 3D-view

3.1.4.12

N-dodecanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + H2O = 4-nitrobenz-2-oxa-1,3-diazole-N-dodecanoylsphingosine + choline phosphate

651708

5i85, 3D-view

3.1.4.12

N-dodecanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + H2O = 4-nitrobenz-2-oxa-1,3-diazole-N-dodecanoylsphingosine + choline phosphate

651708

5tcd, 3D-view

3.1.4.12

N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + H2O = 4-nitrobenz-2-oxa-1,3-diazole-N-hexanoylsphingosine + choline phosphate

651708

5i85, 3D-view

3.1.4.12

N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + H2O = 4-nitrobenz-2-oxa-1,3-diazole-N-hexanoylsphingosine + choline phosphate

651708

5tcd, 3D-view

3.1.4.12

N-methyl-sphingomyelin + H2O = N-methyl-N-acylsphingosine + choline phosphate

0

5i85, 3D-view

3.1.4.12

N-methyl-sphingomyelin + H2O = N-methyl-N-acylsphingosine + choline phosphate

0

5tcd, 3D-view

3.1.4.12

p-nitrophenylphosphorylcholine + H2O = choline phosphate + p-nitrophenol

0

5i85, 3D-view

3.1.4.12

p-nitrophenylphosphorylcholine + H2O = choline phosphate + p-nitrophenol

0

5tcd, 3D-view

3.1.4.12

phosphatidylcholine + H2O = diacylglycerol + choline phosphate

0, 652706

5i85, 3D-view

3.1.4.12

phosphatidylcholine + H2O = diacylglycerol + choline phosphate

0, 652706

5tcd, 3D-view

3.1.4.12

platelet-activating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate

0

5i85, 3D-view

3.1.4.12

platelet-activating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate

0

5tcd, 3D-view

3.1.4.12

platelet-inactivating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate + ?

0

5i85, 3D-view

3.1.4.12

platelet-inactivating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate + ?

0

5tcd, 3D-view

3.1.4.12

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

0, 652079, 135146, 135153, 135168, 135179, 135180, 651148, 651338, 652444, 652543, 653119, 135163, 135170, 135183, 650323, 651315, 652706, 652974, 653103, 653120, 652090, 652972, 135182, 651708, 135166, 650366, 650502, 650584, 651801, 652701, 649984, 649682, 649563, 652601, 652461, 653652, 652373, 135172, 135173

5i85, 3D-view

3.1.4.12

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

0, 652079, 135146, 135153, 135168, 135179, 135180, 651148, 651338, 652444, 652543, 653119, 135163, 135170, 135183, 650323, 651315, 652706, 652974, 653103, 653120, 652090, 652972, 135182, 651708, 135166, 650366, 650502, 650584, 651801, 652701, 649984, 649682, 649563, 652601, 652461, 653652, 652373, 135172, 135173

5tcd, 3D-view

3.1.4.12

sphingosylphosphocholine + H2O = sphingosine + choline phosphate

651338

5i85, 3D-view

3.1.4.12

sphingosylphosphocholine + H2O = sphingosine + choline phosphate

651338

5tcd, 3D-view

3.1.4.12

sphingosylphosphorylcholine + H2O = sphingosine + choline phosphate

651708

5i85, 3D-view

3.1.4.12

sphingosylphosphorylcholine + H2O = sphingosine + choline phosphate

651708

5tcd, 3D-view

3.1.4.12

1-O-octadecyl-2-lyso-platelet-activating factor + H2O = 1-O-octadecyl-sn-glycerol + phosphocholine

0

5i85, 3D-view

3.1.4.12

1-O-octadecyl-2-lyso-platelet-activating factor + H2O = 1-O-octadecyl-sn-glycerol + phosphocholine

0

5tcd, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + phosphocholine

0

5i85, 3D-view

3.1.4.12

a sphingomyelin + H2O = a ceramide + phosphocholine

0

5tcd, 3D-view

3.1.4.12

BODIPY FL C12-sphingomyelin + H2O = BODIPY FL C12-ceramide + phosphocholine

0

5i85, 3D-view

3.1.4.12

BODIPY FL C12-sphingomyelin + H2O = BODIPY FL C12-ceramide + phosphocholine

0

5tcd, 3D-view

3.1.4.12

CDP-choline + H2O = CMP + phosphocholine

0

5i85, 3D-view

3.1.4.12

CDP-choline + H2O = CMP + phosphocholine

0

5tcd, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphocholine

0

5i85, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphocholine

0

5tcd, 3D-view

3.1.4.12

4-nitrophenyl phosphorylcholine + H2O = 4-nitrophenol + phosphorylcholine

0

5i85, 3D-view

3.1.4.12

4-nitrophenyl phosphorylcholine + H2O = 4-nitrophenol + phosphorylcholine

0

5tcd, 3D-view

3.1.4.12

6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O = 6-hexadecanoylamino-4-methylumbelliferone + phosphorylcholine

0

5i85, 3D-view

3.1.4.12

6-hexadecanoylamino-4-methylumbelliferyl-phosphorylcholine + H2O = 6-hexadecanoylamino-4-methylumbelliferone + phosphorylcholine

0

5tcd, 3D-view

3.1.4.12

CDP-choline + H2O = CMP + phosphorylcholine

0

5i85, 3D-view

3.1.4.12

CDP-choline + H2O = CMP + phosphorylcholine

0

5tcd, 3D-view

3.1.4.12

N-[[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-hexanoyl]-sphingosine-1-phosphocholine + H2O = N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine + phosphorylcholine

0

5i85, 3D-view

3.1.4.12

N-[[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-hexanoyl]-sphingosine-1-phosphocholine + H2O = N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine + phosphorylcholine

0

5tcd, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphorylcholine

0

5i85, 3D-view

3.1.4.12

sphingomyelin + H2O = ceramide + phosphorylcholine

0

5tcd, 3D-view

3.1.4.1

2 entries

3.1.4.12

68 entries

3.1.4.2

p-nitrophenylphosphocholine + H2O = p-nitrophenol + phosphocholine

95133

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + choline phosphate

0

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate

0

-

3.1.4.3

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

0

-

3.1.4.3

1,2-dibutyryl-sn-glycero-3-phosphocholine + H2O = 1,2-dibutyryl-sn-glycerol + phosphocholine

0

-

3.1.4.3

1,2-diheptanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-diheptanoyl-sn-glycerol + phosphocholine

0

-

3.1.4.3

1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexanoyl-sn-glycerol + phosphocholine

0

-

3.1.4.3

1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioleoyl-sn-glycerol + phosphocholine

0

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-sn-diacylglycerol + phosphocholine

0

-

3.1.4.3

sphingomyelin + H2O = ceramide + phosphocholine

652656, 0

-

3.1.4.3

1,2-dicaproylphosphatidylcholine + H2O = 1,2-dicaproylglycerol + phosphorylcholine

135304

-

3.1.4.3

1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexanoyl-sn-glycerol + phosphorylcholine

649967

-

3.1.4.3

1,2-dilauroylphosphatidylcholine + H2O = 1,2-dilaureoylglycerol + phosphorylcholine

135286

-

3.1.4.3

1,2-dimyristoylphosphatidylcholine + H2O = 1,2-dimyristoylglycerol + phosphorylcholine

135304

-

3.1.4.3

1,2-dioleoylphosphatidylcholine + H2O = 1,2-dioleoylglycerol + phosphorylcholine

135301

-

3.1.4.3

1,2-dipalmitoylphosphatidylcholine + H2O = 1,2-dipalmitoylglycerol + phosphorylcholine

0, 135289, 135304, 135293

-

3.1.4.3

1-arachidonoyl-2-lysophosphatidylcholine + H2O = 1-arachidonoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-arachidoyl-2-lysophosphatidylcholine + H2O = 1-arachidoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-lauroyl-lysophosphatidylcholine + H2O = 1-lauroyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-linoleoyl-lysophosphatidylcholine + H2O = 1-linoleoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-myristoyl-lysophosphatidylcholine + H2O = 1-myristoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-oleoyl-lysophosphatidylcholine + H2O = 1-oleoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-palmitoyl-lysophosphatidylcholine + H2O = 1-palmitoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

1-palmitoyl-lysophosphatidylcholine + H2O = monopalmitoylglycerol + phosphorylcholine

652656

-

3.1.4.3

1-stearoyl-lysophosphatidylcholine + H2O = 1-stearoyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

4-nitrophenylphosphorylcholine + H2O = 4-nitrophenol + phosphorylcholine

0

-

3.1.4.3

BODIPY-phosphatidylcholine + H2O = BODIPY-1,2-diacyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

diheptanoylphosphatidylcholine + H2O = diheptanoylglycerol + phosphorylcholine

135281

-

3.1.4.3

dihexanoylphosphatidylcholine + H2O = dihexanoylglycerol + phosphorylcholine

135281

-

3.1.4.3

dimyristoylphosphatidylcholine + H2O = dimyristoylglycerol + phosphorylcholine

0

-

3.1.4.3

egg lysophosphatidylcholine + H2O = monoacylglycerol + phosphorylcholine

0

-

3.1.4.3

glycerophosphorylcholine + H2O = glycerol + phosphorylcholine

0

-

3.1.4.3

lysophosphatidylcholine + H2O = monoacylglycerol + phosphorylcholine

135286, 135297, 133931, 135298, 135305, 135306, 135307

-

3.1.4.3

p-nitrophenyl phosphorylcholine + H2O = p-nitrophenol + phosphorylcholine

0

-

3.1.4.3

p-nitrophenylphosphoryl-choline + H2O = p-nitrophenol + phosphorylcholine

0

-

3.1.4.3

p-nitrophenylphosphorylcholine + H2O = p-nitrophenol + phosphorylcholine

135297, 0, 653091, 135293

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphorylcholine

0

-

3.1.4.3

phosphatidylcholine + H2O = 1,2-diacylglycerol + phosphorylcholine

135280, 0, 135301, 94309, 135289, 135286, 135297, 133931, 135299, 135304, 135308, 135293, 135296, 135298, 135303, 649438, 135292, 135305, 135306, 135307, 653091

-

3.1.4.3

sphingomyelin + H2O = ceramide + phosphorylcholine

135286, 135297, 0, 133931, 135299, 135308, 135296, 135298, 135292, 135307

-

3.1.4.38

p-aminophenylphosphocholine + H2O = p-aminophenol + choline phosphate

0

1wra, 3D-view

3.1.4.38

p-aminophenylphosphocholine + H2O = p-aminophenol + choline phosphate

0

5egh, 3D-view

3.1.4.38

p-nitrophenylphosphocholine + H2O = p-nitrophenol + choline phosphate

0

1wra, 3D-view

3.1.4.38

p-nitrophenylphosphocholine + H2O = p-nitrophenol + choline phosphate

0

5egh, 3D-view

3.1.4.38

sn-glycero-3-phosphocholine + H2O = glycerol + choline phosphate

0

1wra, 3D-view

3.1.4.38

sn-glycero-3-phosphocholine + H2O = glycerol + choline phosphate

0

5egh, 3D-view

3.1.4.38

4-nitrophenyl phosphocholine + H2O = 4-nitrophenol + phosphocholine

0

1wra, 3D-view

3.1.4.38

4-nitrophenyl phosphocholine + H2O = 4-nitrophenol + phosphocholine

0

5egh, 3D-view

3.1.4.38

sn-glycero-3-phosphocholine + H2O = glycerol + phosphocholine

0

1wra, 3D-view

3.1.4.38

sn-glycero-3-phosphocholine + H2O = glycerol + phosphocholine

0

5egh, 3D-view

3.1.4.38

sn-glycerol-3-phosphocholine + H2O = glycerol + phosphocholine

0

1wra, 3D-view

3.1.4.38

sn-glycerol-3-phosphocholine + H2O = glycerol + phosphocholine

0

5egh, 3D-view

3.6.1.13

CDP-choline + H2O = CMP + choline phosphate

0

-

3.6.1.13

CDP-choline + H2O = CMP + phosphocholine

0

-

3.1.4.3

38 entries

3.1.4.38

12 entries

3.6.1.13

2 entries

3.6.1.53

CDP-choline + H2O = CMP + phosphocholine

0

-

3.6.1.9

CDP-choline + H2O = CMP + phosphorylcholine

246812

-

Activator in Enzyme-catalyzed Reactions (4 results)

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Show Activating Compound (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.34

phosphocholine in combination with Ca2+ markedly stimulate the formation of leukotrienes by wild-type 5-LO and mutant C159S/C300S/C416S/C418S, whereas their effect on the 5-LO W13A/W75A/W102A mutant is small

741975

-

2.3.1.20

from soy bean, activation

486491

-

3.4.21.20

phospholipid vesicles containing phosphatidyl-L-serine and phosphocholine are required for enzyme-mediated thrombin production in platelet-free plasma, potentially due to protection of lipid bound enzyme from inhibition

652509

-

7.5.2.6

2fold stimulation of MsbA

698746

-

Inhibitor in Enzyme-catalyzed Reactions (27 results)

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Show Inhibitors (27 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.103

-

485056, 485062

5wp4, 3D-view

2.1.1.103

47% activity in the presence of 1 mM, 17% activity in the presence of 5 mM

719882

5wp4, 3D-view

2.1.1.103

competitive feedback inhibition; feedback inhibition

671898

5wp4, 3D-view

2.1.1.103

product inhibition, 50% inhibition at 0.05 mM

663227

5wp4, 3D-view

2.7.1.32

-

641347

2ckq, 3D-view

2.7.1.32

40% and 66% inhibition at 2.5 mM and 10 mM, respectively

672361

2ckq, 3D-view

2.7.1.32

-

641361, 641362, 641372

2ckq, 3D-view

2.7.1.82

-

641347

2ckq, 3D-view

2.7.1.82

-

642036

2ckq, 3D-view

2.7.1.82

not

641350, 642038

2ckq, 3D-view

2.7.7.14

a weak competitive inhibitor of Pcyt2

722415

-

2.7.7.14

weak, competitive to phosphoethanolamine

642887

-

2.1.1.103

4 entries

2.7.1.32

3 entries

2.7.1.82

3 entries

2.7.7.14

2 entries

2.8.2.6

dead-end inhibitor, competitive inhibition with choline, linear mixed type inhibitor with respect to PAPS

643829

-

3.1.1.47

25% inhibition at 0.05 mM

653094

-

3.1.3.16

-

701201

-

3.1.3.2

-

666336

-

3.1.3.2

substrate inhibition

666338

-

3.1.3.2

2 entries

3.1.3.3

-

81056

-

3.1.3.75

substrate inhibition at high concentration

714357, 714874

-

3.1.3.75

-

714872

-

3.1.4.12

-

135179

5i85, 3D-view

3.1.4.12

-

135179

5tcd, 3D-view

3.1.4.12

23% inhibition

135173

5i85, 3D-view

3.1.4.12

23% inhibition

135173

5tcd, 3D-view

3.1.4.38

-

95162

1wra, 3D-view

3.1.4.38

-

95162

5egh, 3D-view

3.1.3.75

2 entries

3.1.4.12

4 entries

3.1.4.38

2 entries

3.1.6.6

competitive inhibition

135659, 135665

-

Metals and Ions (1 result)

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Show Metals Ions (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.21.6

best in lipid vesicles with up to 25% phosphatidyl-L-serine and at least 75% phosphocholine

652682

-

3D Structure of Enzyme-Ligand-Complex (PDB) (41 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (41 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.1.1.103

5wp4, 3D-view

2.4.2.43

5ezm, 3D-view

2.7.1.32

2ckq, 3D-view

2.7.1.82

2ckq, 3D-view

2.7.7.15

4zcr, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.12

5i85, 3D-view

3.1.4.12

5tcd, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.38

1wra, 3D-view

3.1.4.38

5egh, 3D-view

3.1.4.12

18 entries

3.1.4.38

18 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (14 results)

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Show Turnover Number (14 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.7.15

0.21

-

wild-type, absence of lipid

642916

2.7.7.15

0.5

-

H92N mutant, purified enzyme, 37°C

642924

2.7.7.15

1.51

-

absence of lipid

642918

2.7.7.15

1.63

-

H92Q mutant, purified enzyme, 37°C

642924

2.7.7.15

2.22

-

wild-type, purified enzyme, 37°C

642924

2.7.7.15

11.1

-

CCTalpha236 mutant, presence of lipid

642916

2.7.7.15

12.6

-

CCTalpha236 mutant, absence of lipid

642916

2.7.7.15

17.5

-

pH 8, 37°C

642912

2.7.7.15

17.7

-

wild-type, presence of lipid

642916

2.7.7.15

31.3

-

presence of lipid

642918

2.7.7.15

10 entries

3.1.3.2

33.24

-

pH 37°C, pH 5.6, 1 mM MgCl2, Vmax: 89.58 micromol/min/mg

715966

3.1.3.75

1.04

-

50 mM Hepes/NaOH buffer, pH 7.0, 37°C

714360

3.1.3.75

1.98

-

pH 6.7, 37°C, 2 mM Mg2+

654549

3.1.3.75

2 entries

3.1.6.6

0.027

-

wild-type, pH 7.6, 25°C

751335

K_M Value (60 results)

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Show KM Value (60 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.7.14

6.2

-

pH 7.8, 37°C

642887

2.7.7.15

0.083

-

pH 7, 37°C

642922

2.7.7.15

0.14

-

pH 7.5

642894

2.7.7.15

0.167

-

L-form, pH 6.4, 37°C

642897

2.7.7.15

0.17

-

pH 6.5, 37°C, L-form of enzyme

642890

2.7.7.15

0.17

-

pH 7, 37°C

642907

2.7.7.15

0.18

-

H-form, pH 6.4, 37°C

642897

2.7.7.15

0.22

-

catalytic subunit

642895

2.7.7.15

0.24

-

pH 7, 37°C

642889

2.7.7.15

0.3

-

pH 7.4, 37°C

642893

2.7.7.15

0.33

-

wild-type deletion construct 1-236, 8.8 mM CTP

704587

2.7.7.15

0.37

-

pH 7.5

642901

2.7.7.15

0.39

-

pH 8, 37°C

642912

2.7.7.15

0.45

-

wild-type, pH 7, 37°C

642919

2.7.7.15

0.48

-

Y173A mutant deletion construct 1-236, 8.8 mM CTP

704587

2.7.7.15

0.48

-

wild-type, cytosolic enzyme, 37°C

642924

2.7.7.15

0.49

-

presence of lipid, pH 7.4, 37°C

642927

2.7.7.15

0.5

-

purified native enzyme, pH 7.0, 37°C

661238

2.7.7.15

0.52

-

pH 7, 37°C

642906

2.7.7.15

0.56

-

wild-type, purified enzyme, 37°C

642924

2.7.7.15

0.63

-

isozyme CCT2

690911

2.7.7.15

0.64

-

purified His-tagged enzyme, pH 7.0, 37°C

661238

2.7.7.15

0.65

-

wild-type, presence of lipid

642916

2.7.7.15

0.66

-

absence of lipid, pH 7.4, 37°C

642927

2.7.7.15

0.8

-

presence of lipid

642918

2.7.7.15

0.87

-

H92Q mutant, cytosolic and purified enzyme, 37°C

642924

2.7.7.15

0.9

-

CCTalpha236 mutant, absence of lipid

642916

2.7.7.15

0.97

-

CCTalpha236 mutant, presence of lipid

642916

2.7.7.15

0.98

-

H89N mutant, cytosolic enzyme, 37°C

642924

2.7.7.15

1.05

-

wild-type, absence of lipid

642916

2.7.7.15

1.1

-

pH 7.6, 30°C

642899

2.7.7.15

1.18

-

absence of lipid

642918

2.7.7.15

2.1

-

pH 7

642891

2.7.7.15

2.29

-

isozyme CCT1

690911

2.7.7.15

2.35

-

R196K mutant, pH 7, 37°C

642919

2.7.7.15

2.4

-

H92N mutant, cytosolic enzyme, 37°C

642924

2.7.7.15

2.49

-

K0.5 value, Hill coefficient 0.992, pH 7.0, 37°C

737438

2.7.7.15

2.49

-

pH 7.0, 37°C, enzyme mutant CCTalpha236

737438

2.7.7.15

2.5

-

H168A mutant deletion construct 1-236, 8.8 mM CTP

704587

2.7.7.15

2.65

-

H92N mutant, purified enzyme, 37°C

642924

2.7.7.15

3.2

-

H168A/Y173A mutant deletion construct 1-236, 8.8 mM CTP

704587

2.7.7.15

36

-

K122R mutant, pH 7, 37°C

642919

2.7.7.15

212

-

K122A mutant, pH 7, 37°C

642919

2.7.7.15

42 entries

3.1.1.3

1.02

-

pH 7.5, 37°C

653521

3.1.3.2

0.2

-

pH 5.0, 37°C

666338

3.1.3.2

0.47

-

pH 37°C, pH 5.6, 1 mM MgCl2, Vmax: 89.58 micromol/min/mg

715966

3.1.3.2

3.3

-

prostatic enzyme

134741

3.1.3.2

4

-

isoenzyme PAP-I

134726

3.1.3.2

4.6

-

urinary enzyme

134741

3.1.3.2

10

-

isoenzyme PAP-II

134726

3.1.3.75

0.0114

-

pH 6.7, 37°C, 2 mM Mg2+

654549

3.1.3.75

0.03

-

at pH 5 and pH 7.4, without signal peptide

679380

3.1.3.75

0.03

-

mutant T35S

679380

3.1.3.75

0.05

-

at pH 5 and pH 7.4, with signal peptide

679380

3.1.3.75

0.44

-

50 mM Hepes/NaOH buffer, pH 7.0, 37°C

714360

3.1.3.75

0.5

-

at pH 5 and pH 7.4, without signal peptide

679380

3.1.3.75

0.5

-

mutant T35S

679380

3.1.3.75

3.5

-

at pH 7.4, with signal peptide

679380

3.1.3.75

3.6

-

at pH 5, with signal peptide

679380

3.1.3.2

6 entries

3.1.3.75

9 entries

3.1.6.6

2.1

-

wild-type, pH 7.6, 25°C

751335

K_i Value (8 results)

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Show KI Value (8 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.1.103

5

-

about, pH 8.0, 30°C, recombinant enzyme

671898

2.1.1.103

6.94

-

30°C, pH 8, varied substrate: ethanolamine phosphate

671898

2.1.1.103

7.81

-

30°C, pH 8, varied substrate: S-adenosyl-L-methionine

671898

2.1.1.103

3 entries

2.7.1.32

3.45

-

in 100 mM Tris/HCl, 6 mM MgCl2, 5 mM ATP, pH 8.8, at 37°C

672361

2.7.7.14

52.9

-

pH 7.8, 37°C

642887

2.8.2.6

0.42

-

pH 7.8, 37°C

643829

2.8.2.6

9.4

-

pH 7.8, 37°C

643829

2.8.2.6

2 entries

3.1.3.2

1

-

pH 5.0, 37°C

666338

References & Links

Literature References (204)

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Show Reference (204 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

81056

9430431

Novel phosphoserine phosphatase inhibitors

1997

Hawkinson, J.E.; Acosta-Burruel, M.; Ta, N.D.; Wood, P.L.

Eur. J. Pharmacol.

337

315-324

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