Ligand 5-aminolevulinate

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Basic Ligand Information

Molecular Structure
Picture of 5-aminolevulinate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H9NO3
5-aminolevulinate
ZGXJTSGNIOSYLO-UHFFFAOYSA-N
Synonyms:
5-Amino-4-oxopentanoate, 5-amino-levulinate, 5-aminolevulinic acid, amino levulinic acid, delta-aminolevuinate, delta-aminolevulinic acid


Show all pahtways known for Show all BRENDA pathways known for 5-aminolevulinate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2
show the reaction diagram
-
L-alanine + 4,5-dioxopentanoate = 5-aminolevulinate + pyruvate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-aminolevulinic acid + pyruvate = 5-oxolevulinic acid + L-alanine
show the reaction diagram
-
ATP + H2O + delta-aminolevulinic acid/in = ADP + phosphate + delta-aminolevulinic acid/out
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate + 4,5-dioxopentanoate = 5-aminolevulinate + 2-oxoglutarate
show the reaction diagram
-
-
ATP + H2O + delta-aminolevulinic acid/in = ADP + phosphate + delta-aminolevulinic acid/out
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates, effects on wild-type and mutant enzymes, overview
-
0.01 mM, increases activity
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
beta-alanine as substrate
-
indirect inhibition, growth of Acidithiobacillus ferrooxidans in aminolevulic acid inhibits the activity of GluRS1, the reduced activity of GluRS1 is the result of an interaction of the enzyme with heme or any other intermediate tetrrapyrrole, amino levulic acid added to the reaction mixture has no effect in the activity of GluRSs
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
16.1
-
-

KM Value (35 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.23
-
versus glycine

References & Links

Links to other databases for 5-aminolevulinate

ChEBI
PubChem
ChEBI
PubChem