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Ligand 4-diethyl phosphate acetophenone

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.8.1

4-diethyl phosphate acetophenone + H2O = 4-hydroxyacetophenone + diethyl phosphate

664111

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3.1.8.1

diethyl 4-acetophenyl phosphate + H2O = diethyl phosphate + 4-hydroxyacetophenone

749938

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3.1.8.1

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.8.1

0.44

-

pH 8.0

664111

3.1.8.1

0.6

-

pH and temperature not specified in the publication

749938

3.1.8.1

8080

-

pH 8.0, genetic variant PON1 G2E6

664111

3.1.8.1

3 entries

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.8.1

0.24

-

pH and temperature not specified in the publication

749938

3.1.8.1

1.56

-

pH 8.0

664111

3.1.8.1

2 entries

References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

664111

15835926

Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase

2005

Khersonsky, O.; Tawfik, D.S.

Biochemistry

44

6371-6382

749938

30730705

Transition State Analysis of the Reaction Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1

2019

Bigley, A.N.; Xiang, D.F.; Narindoshvili, T.; Burgert, C.W.; Hengge, A.C.; Raushel, F.M.

Biochemistry

58

1246-1259

Links to other databases for 4-diethyl phosphate acetophenone

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Show Links (1 entry)

ChEBI

PubChem

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