Ligand 1D-myo-inositol 1,4,6-trisphosphate

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Basic Ligand Information

Molecular Structure
Picture of 1D-myo-inositol 1,4,6-trisphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H15O15P3
1D-myo-inositol 1,4,6-trisphosphate
MMWCIQZXVOZEGG-GSRZWBRNSA-N
Synonyms:
1D-myo-inositol-1,4,6-trisphosphate, 1D-myo-inositol-3,4,6-trisphosphate, 1D-myo-inositol 3,4,6-trisphosphate, myo-inositol 1,4,6-trisphosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1D-myo-inositol 1,4,6-trisphosphate + ATP = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,6-trisphosphate + phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
IC50: about 0.0007 mM. Potently reduces conversion of 1D-myo-inositol 1,4,5-trisphosphate to 1D-myo-inositol 1,4,5,6-tetrakisphosphate + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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Enzyme Kinetic Parameters

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0007
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IC50: about 0.0007 mM. Potently reduces conversion of 1D-myo-inositol 1,4,5-trisphosphate to 1D-myo-inositol 1,4,5,6-tetrakisphosphate + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

References & Links

Links to other databases for 1D-myo-inositol 1,4,6-trisphosphate

ChEBI
PubChem
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PubChem