print visible entries

print all entries

Ligand L-tryptophanyl-tRNATrp

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

top print hide

Show Natural Substrate (6 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.20

L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp = 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)

735351

-

2.3.2.B16

2 L-tryptophanyl-tRNATrp = 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)

735351, 758682, 759890

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-alanyl-tRNAAla = tRNATrp + tRNAAla + cyclo(L-tryptophanyl-L-alanyl)

758682

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-leucyl-tRNALeu = tRNATrp + tRNALeu + cyclo(L-tryptophanyl-L-leucyl)

758682, 778303

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-prolyl-tRNAPro = tRNATrp + tRNAPro + cyclo(L-tryptophanyl-L-prolyl)

759890, 758682

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-valyl-tRNAVal = tRNATrp + tRNAVal + cyclo(L-tryptophanyl-L-valyl)

759890

-

2.3.2.B16

5 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.1.1.2

ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophanyl-tRNATrp

-

-

Substrate in Enzyme-catalyzed Reactions (13 results)

top print hide

Show Substrate (13 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.2.20

L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp = 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)

735351

-

2.3.2.B16

2 L-tryptophanyl-tRNATrp = 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)

735351, 758682, 759890

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-alanyl-tRNAAla = tRNATrp + tRNAAla + cyclo(L-tryptophanyl-L-alanyl)

758682

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-leucyl-tRNALeu = tRNATrp + tRNALeu + cyclo(L-tryptophanyl-L-leucyl)

758682, 778303

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-prolyl-tRNAPro = tRNATrp + tRNAPro + cyclo(L-tryptophanyl-L-prolyl)

759890, 758682

-

2.3.2.B16

L-tryptophanyl-tRNATrp + L-valyl-tRNAVal = tRNATrp + tRNAVal + cyclo(L-tryptophanyl-L-valyl)

759890

-

2.3.2.B23

2 L-tryptophanyl-tRNATrp = 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)

778700

-

2.3.2.B23

L-tryptophanyl-tRNATrp + L-alanyl-tRNAAla = tRNATrp + tRNAAla + cyclo(L-tryptophanyl-L-alanyl)

776322

-

2.3.2.B23

L-tryptophanyl-tRNATrp + L-leucyl-tRNALeu = tRNATrp + tRNALeu + cyclo(L-tryptophanyl-L-leucyl)

776322

-

2.3.2.B23

L-tryptophanyl-tRNATrp + L-phenylalanyl-tRNAPhe = tRNATrp + tRNAPhe + cyclo(L-tryptophanyl-L-phenylalanyl)

776322

-

2.3.2.B23

L-tryptophanyl-tRNATrp + L-prolyl-tRNAPro = tRNATrp + tRNAPro + cyclo(L-tryptophanyl-L-prolyl)

776322

-

2.3.2.B23

L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp = 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)

776466

-

2.3.2.B23

L-tryptophanyl-tRNATrp + L-tyrosyl-tRNATyr = tRNATrp + tRNATyr + cyclo(L-tryptophanyl-L-tyrosyl)

776322

-

2.3.2.B16

5 entries

2.3.2.B23

7 entries

Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.1.1.2

ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophanyl-tRNATrp

-

-

Enzyme Kinetic Parameters

References & Links

Literature References (8)

top print hide

Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

735351

26641496

Two distinct cyclodipeptide synthases from a marine actinomycete catalyze biosynthesis of the same diketopiperazine natural product

2016

James, E.D.; Knuckley, B.; Alqahtani, N.; Porwal, S.; Ban, J.; Karty, J.A.; Viswanathan, R.; Lane, A.L.

ACS Synth. Biol.

5

547-553

758682

29574613

Expanding tryptophan-containing cyclodipeptide synthase spectrum by identification of nine members from Streptomyces strains

2018

Liu, J.; Yu, H.; Li, S.M.

Appl. Microbiol. Biotechnol.

102

4435-4444

758682

29574613

Expanding tryptophan-containing cyclodipeptide synthase spectrum by identification of nine members from Streptomyces strains

2018

Liu, J.; Yu, H.; Li, S.M.

Appl. Microbiol. Biotechnol.

102

4435-4444

758682

2 entries

759890

30688950

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

2019

Borgman, P.; Lopez, R.; Lane, A.

Org. Biomol. Chem.

17

2305-2314

776322

37183364

Production of diketopiperazine derivatives by pathway engineering with different cyclodipeptide synthases from various Streptomyces strains

2023

Stierle, S.A.; Harken, L.; Li, S.M.

ACS Synth. Biol.

12

1804-1812

776466

33741615

Deciphering a cyclodipeptide synthase pathway encoding prenylated indole alkaloids in Streptomyces leeuwenhoekii

2021

Zhang, Y.; Yao, T.; Jiang, Y.; Li, H.; Yuan, W.; Li, W.

Appl. Environ. Microbiol.

87

e02525

778303

39653608

Divergent metabolism of cyclo-L-Trp-L-Leu in Streptomyces albofaciens by hydroxylation and nucleobase transfer with two cytochrome P450 enzymes

2024

Dai, Y.; Ostendorff, D.; Li, S.M.

J. Nat. Prod.

87

2716-2723

778700

37137876

Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase

2023

Deletti, G.; Green, S.D.; Weber, C.; Patterson, K.N.; Joshi, S.S.; Khopade, T.M.; Coban, M.; Veek-Wilson, J.; Caulfield, T.R.; Viswanathan, R.; Lane, A.L.

Nat. Commun.

14

2558

Links to other databases for L-tryptophanyl-tRNATrp

top print hide

Show Links (1 entry)