Ligand trehalose phosphate

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Basic Ligand Information

Molecular Structure
Picture of trehalose phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C12H23O14P
trehalose phosphate
LABSPYBHMPDTEL-LIZSDCNHSA-N
Synonyms:
alpha,alpha'-Trehalose 6-phosphate, alpha,alpha-1,1-trehalose 6-phosphate, alpha,alpha-trehalose 6-phosphate, alpha,alpha-trehalose 6-phosphate[side 2], trehalose-6-phosphate, trehalose 6-phosphate


Show all pahtways known for Show all BRENDA pathways known for trehalose phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glucose 6-phosphate + beta-D-glucose 1-phosphate = alpha,alpha-trehalose 6-phosphate + phosphate
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GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate
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[protein]-Npi-phospho-L-histidine + alpha,alpha-trehalose[side 1] = [protein]-L-histidine + alpha,alpha-trehalose 6-phosphate[side 2]
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate
show the reaction diagram
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trehalose 6-phosphate + H2O = trehalose + phosphate
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trehalose 6-phosphate + H2O = trehalose + phosphate
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trehalose 6-phosphate + H2O = ?
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Product in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
glucose 6-phosphate + beta-D-glucose 1-phosphate = alpha,alpha-trehalose 6-phosphate + phosphate
show the reaction diagram
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[protein]-Npi-phospho-L-histidine + alpha,alpha-trehalose[side 1] = [protein]-L-histidine + alpha,alpha-trehalose 6-phosphate[side 2]
show the reaction diagram
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UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
59% inhibition at 10 mM
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more than 90% inhibition at 1 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (32 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (46 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.47
-
-
1.16
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pH 7.5

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.012
-
pH 7.5, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.201
-
at pH 7.0 and 25°C

References & Links

Links to other databases for trehalose phosphate

ChEBI
PubChem
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PubChem