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Ligand 1-Hydroxypyrene

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (13 results)

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Show Substrate (13 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.2.1

1-pyrenol + H2O2 = 1,8-dihydroxypyrene + 1,6-dihydroxypyrene + H2O

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2.1.1.6

S-adenosyl-L-methionine + 1-hydroxypyrene = S-adenosyl-L-homocysteine + ?

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2.4.1.17

1-hydroxy-pyrene + UDP-D-xylose = pyrene 1-O-D-xyloside + UDP

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2.4.1.17

1-hydroxypyrene + UDP-D-glucose = pyrene 1-O-D-glucoside + UDP

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2.4.1.17

1-hydroxypyrene + UDP-glucuronate = 1-hydroxypyrene 1-O-glucuronate + UDP

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2.4.1.17

1-hydroxypyrene + UDP-glucuronate = ?

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2.4.1.17

1-hydroxypyrene + UDP-glucuronate = pyrene 1-O-glucuronide + UDP

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2.4.1.17

1-hydroxypyrene + UDP-glucuronate = UDP + 1-hydroxypyrene-1-O-glucuronide

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2.4.1.17

1-hydroxypyrene + UDP-N-acetylglucosamine = pyrenil-1-O-(N-acetylglucosaminide) + UDP

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2.4.1.17

UDP-glucuronate + 1-hydroxypyrene = UDP + 1-hydroxypyrene beta-D-glucuronoside

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2.4.1.17

1-hydroxy[a]pyrene + UDP-glucuronate = UDP + benzo[a]pyren-1-yl-alpha-D-glucuronide

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2.4.1.17

9 entries

2.8.2.1

3'-phosphoadenylyl sulfate + 1-hydroxypyrene = adenosine 3',5'-bisphosphate + 1-hydroxypyrene sulfate

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2.8.2.2

3'-phosphoadenylylsulfate + 1-hydroxypyrene = adenosine 3',5'-bisphosphate + 1-hydroxypyrene sulfate

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Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.2.1

pyrene + H2O2 = 1-pyrenol + H2O

0

-

1.14.15.1

pyrene + putidaredoxin + O2 = 1-pyrenol + 2-pyrenol + 1,6-pyrenequinone + 1,8-pyrenequinone + oxidized putidaredoxin + H2O

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.8.2.1

2

-

wild-type, initial rate value, pH 7.5, 25°C

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K_M Value (12 results)

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Show KM Value (12 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.17

0.0012

-

with UDP-D-xylose, recombinant enzyme in microsomes, pH 7.4, 37°C

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2.4.1.17

0.003188

-

at pH 7.4 and 38.5°C

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2.4.1.17

0.0033

-

with UDP-D-glucose, recombinant enzyme in microsomes, pH 7.4, 37°C

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2.4.1.17

0.019

-

at pH 7.4 and 38.5°C

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2.4.1.17

0.02548

-

at pH 7.4 and 40.5°C

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2.4.1.17

0.03662

-

at pH 7.4 and 41.5°C

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2.4.1.17

0.06745

-

at pH 7.4 and 38.5°C

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2.4.1.17

0.091

-

wild-type, pH 7.4, 37°C

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2.4.1.17

0.111

-

mutant K75R, pH 7.4, 37°C

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2.4.1.17

0.1137

-

at pH 7.4 and 42°C

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2.4.1.17

2.326

-

at pH 7.4 and 39°C

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2.4.1.17

11 entries

2.8.2.1

0.000022

-

wild-type, initial rate value, pH 7.5, 25°C

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References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

659631

15549609

Evidence for the existence of PAH-quinone reductase and catechol-O-methyltransferase in Mycobacterium vanbaalenii PYR-1

2004

Kim, Y.H.; Moody, J.D.; Freeman, J.P.; Brezna, B.; Engesser, K.H.; Cerniglia, C.E.

J. Ind. Microbiol. Biotechnol.

31

507-516

675319

17474732

Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives

2007

Bichlmaier, I.; Kurkela, M.; Joshi, T.; Siiskonen, A.; Rueffer, T.; Lang, H.; Suchanova, B.; Vahermo, M.; Finel, M.; Yli-Kauhaluoma, J.

J. Med. Chem.

50

2655-2664

675594

16120810

Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity

2005

Finel, M.; Li, X.; Gardner-Stephen, D.; Bratton, S.; Mackenzie, P.I.; Radominska-Pandya, A.

J. Pharmacol. Exp. Ther.

315

1143-1149

711334

19823936

Conversion of polycyclic aromatic hydrocarbons, methyl naphthalenes and dibenzofuran by two fungal peroxygenases

2010

Aranda, E.; Ullrich, R.; Hofrichter, M.

Biodegradation

21

267-281

720625

21164388

Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis

2011

Bushey, R.T.; Chen, G.; Blevins-Primeau, A.S.; Krzeminski, J.; Amin, S.; Lazarus, P.

Pharmacogenet. Genomics

21

55-65

735649

25937523

Roles of human UDP-glucuronosyltransferases in clearance and homeostasis of endogenous substrates, and functional implications

2015

Bock, K.W.

Biochem. Pharmacol.

96

77-82

739274

25736839

Detoxification function of the Arabidopsis sulphotransferase AtSOT12 by sulphonation of xenobiotics

2015

Chen, J.; Gao, L.; Baek, D.; Liu, C.; Ruan, Y.; Shi, H.

Plant Cell Environ.

38

1673-1682

756511

30476594

Characterization of function and genetic feature of UDP-glucuronosyltransferase in avian species

2019

Kawai, Y.K.; Shinya, S.; Ikenaka, Y.; Saengtienchai, A.; Kondo, T.; Darwish, W.S.; Nakayama, S.M.M.; Mizukawa, H.; Ishizuka, M.

Comp. Biochem. Physiol. C

217

5-14

759116

31836608

UDP-glycosyltransferase 3A metabolism of polycyclic aromatic hydrocarbons potential importance in aerodigestive tract tissues

2020

Vergara, A.G.; Watson, C.J.W.; Chen, G.; Lazarus, P.

Drug Metab. Dispos.

48

160-168

761471

29038294

The NSAID allosteric site of human cytosolic sulfotransferases

2017

Wang, T.; Cook, I.; Leyh, T.S.

J. Biol. Chem.

292

20305-20312

Links to other databases for 1-Hydroxypyrene

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ChEBI

PubChem