Ligand L-erythro-7,8-dihydrobiopterin

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Basic Ligand Information

Molecular Structure
Picture of L-erythro-7,8-dihydrobiopterin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H13N5O3
L-erythro-7,8-dihydrobiopterin
FEMXZDUTFRTWPE-DZSWIPIPSA-N
Synonyms:
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(8H)-one, 6,7-[8]-dihydrobiopterin, 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydrobiopterin, 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin, 7,8-dihydro-L-biopterin, 7,8-dihydrobiopterin, biopterin-H2, dihydrobiopterin, L-erythro-dihydrobiopterin, quininoid dihydropterin
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihydrobiopterin + NADH + H+ = tetrahydrobiopterin + NAD+
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
show the reaction diagram
-
2 biopterin + 3 NADPH + 3 H+ = dihydrobiopterin + tetrahydrobiopterin + 3 NADP+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-erythro-dihydrobiopterin + NADP+ = ?
show the reaction diagram
-
dihydrobiopterin + NADH + H+ = tetrahydrobiopterin + NAD+
show the reaction diagram
-
dihydrobiopterin + NADPH + H+ = tetrahydrobiopterin + NADP+
show the reaction diagram
-
2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]pteridin-4(8H)-one + H2O = 6-[(1R,2S)-1,2-dihydroxypropyl]pteridine-2,4(1H,3H)-dione + NH3
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (85 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
show the reaction diagram

Enzyme Cofactor/Cosubstrate (5 results)

Inhibitor in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
builds a complex with the enzyme
-

3D Structure of Enzyme-Ligand-Complex (PDB) (257 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.004
-
-
0.03
-
cosubstrate NADPH, pH 7.2, 25°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.07
-
-
0.161
-
recombinant truncated enzyme

References & Links

Links to other databases for L-erythro-7,8-dihydrobiopterin

ChEBI
PubChem
ChEBI
PubChem