Ligand N-alpha-acetyl-L-lysine

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Basic Ligand Information

Molecular Structure
Picture of N-alpha-acetyl-L-lysine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H16N2O3
N-alpha-acetyl-L-lysine
VEYYWZRYIYDQJM-ZETCQYMHSA-N
Synonyms:
acetyl-Lys, acetyl-lysine, alpha-N-acetyl-L-lysine, N-acetyl-L-lysine, N-acetyl-Lys, N-acetyllysine, N2-acetyl-L-Lys, N2-acetyl-L-lysine, N2-acetyl-Lys, Nalpha-acetyl-L-lysine, Nalpha-acetyl-Lys, Nalpha-acetyl-lysine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-N-acetyl-L-lysine + H2O = N-acetyl-6-oxo-L-norleucine + H2O2 + NH3
show the reaction diagram
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N2-acetyl-L-lysine + 2-oxoglutarate = N2-acetyl-L-aminoadipate semialdehyde + L-glutamate
show the reaction diagram
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N-acetyl-L-lysine + H2O = N-acetyl-L-lysine + H2O
show the reaction diagram
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N-acetyl-L-lysine + H2O = acetate + L-lysine
show the reaction diagram
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N-acetyllysine + H2O = acetate + lysine
show the reaction diagram
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Nalpha-acetyl-L-lysine + H2O = L-lysine + acetate
show the reaction diagram
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N2-acetyl-L-lysine + H2O = L-lysine + acetate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N2-acetyl-N6-(5'-phosphopyridoxyl)-L-lysine + H2O + O2 = pyridoxal 5'-phosphate + N2-acetyl-L-lysine + H2O2
show the reaction diagram
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N-acetyl-Lys-tRNA + H2O = N-acetyl-Lys + tRNA
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N6-(N2-acetyl)Lys-ubiquitin + H2O = ubiquitin + N2-acetyl-Lys
show the reaction diagram
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acetyl-Lys methyl ester + H2O = acetyl-Lys + methanol
show the reaction diagram
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Ac-L-Lys-4-nitroanilide + H2O = N2-acetyl-L-Lys + 4-nitroaniline
show the reaction diagram
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N6-(1-hydroxy-2-oxopropyl)-N2-acetyl-L-lysine + H2O = N-acetyl-L-lysine + (R)-lactate
show the reaction diagram
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alpha-N-acetyl-epsilon-(L-gamma-glutamyl)-L-lysine methyl ester = alpha-N-acetyl-L-lysine + 5-oxo-L-proline
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
with benzoyl-Gly-Lys as substrate
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.8
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pH 8.9, 45C

KM Value (8 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
10
-
pH 8.9, 45C
1.59
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pH 9, rate of carboxyl oxygen exchange reaction by Lys-C is accelerated at acidic pH conditions.
1.3
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pH 7.5, 37C
4.1
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References & Links

Links to other databases for N-alpha-acetyl-L-lysine

ChEBI
PubChem
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PubChem