Ligand Dichloromethane

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Basic Ligand Information

Molecular Structure
Picture of Dichloromethane (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH2Cl
Dichloromethane
AVVWPBAENSWJCB-DGPNFKTASA-N
Synonyms:
CH2Cl2, dichlormethane

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dichloromethane + NAD(P)H + O2 = CO + Cl- + NAD(P)+ + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chloroform + reduced acceptor = dichloromethane + chloride + acceptor
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
55% activation of recombinant refolded enzyme at 30% v/v, 67% at 10% v/v
-
enhances the enzyme activity up to 2fold upon permeabilization
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50% (v/v), 80% inhibition
-
competitively in presence of formate
-
0.05 mM: 50% inhibition
-
5% (v/v), 70% inhibition
-
about 30% residual activity at 5% (v/v)
-
an inhibitory effect with increasing dichloromethane concentrations is observed at concentrations higher than 400 mg/l
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (20 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (23 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
100
-
-

References & Links

Links to other databases for Dichloromethane

ChEBI
PubChem
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PubChem