Ligand GDP-ribose
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Basic Ligand Information
C15H23N5O15P2
GDP-ribose
JSQOXYZOPSTQIZ-ZLTLPMJDSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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GDP-ribose + H2O = GMP + D-ribose 5-phosphate
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Product in Enzyme-catalyzed Reactions (2 results)
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nicotinamide guanine dinucleotide + H2O = 3',5'-cyclic GDP-ribose + GDP-ribose
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NGD+ + H2O = GDP-ribose + nicotinamide
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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3.57
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25°C, pH 7.6, wild-type enzyme
KM Value (1 result)
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1.1
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25°C, pH 7.6, wild-type enzyme
References & Links
Literature References (2)
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Molecular mechanism of the Thermus thermophilus ADP-ribose pyrophosphatase from mutational and kinetic studies
2005
Ooga, T.; Yoshiba, S.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
Biochemistry
44
9320-9329
Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis
2006
Liu, Q.; Kriksunov, I.A.; Graeff, R.; Munshi, C.; Lee, H.C.; Hao, Q.
J. Biol. Chem.
281
32861-32869
Links to other databases for GDP-ribose