Ligand 9,10-dihydroxy-benzo(a)pyrene
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Basic Ligand Information
Molecular Structure

C20H12O2
9,10-dihydroxy-benzo(a)pyrene
UMJIZEKULDXYAK-UHFFFAOYSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (8 results)
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benzo[a]pyrene-9,10-diol + UDP-D-glucose = 10-hydroxy-benzo[a]pyrene-9-O-D-glucoside + UDP
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benzo[a]pyrene-9,10-diol + UDP-D-glucose = 9-hydroxy-benzo[a]pyrene-10-O-D-glucoside + UDP
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benzo[a]pyrene-9,10-diol + UDP-D-xylose = 10-hydroxy-benzo[a]pyrene-9-O-D-xyloside + UDP
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benzo[a]pyrene-9,10-diol + UDP-D-xylose = 9-hydroxy-benzo[a]pyrene-10-O-D-xyloside + UDP
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benzo[a]pyrene-9,10-diol + UDP-glucuronate = 10-hydroxy-benzo[a]pyrene-9-O-glucuronide + UDP
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benzo[a]pyrene-9,10-diol + UDP-glucuronate = 9-hydroxy-benzo[a]pyrene-10-O-glucuronide + UDP
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benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine = 10-hydroxybenzo[a]pyrene 9-O-(N-acetylglucosaminide) + UDP
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benzo[a]pyrene-9,10-diol + UDP-N-acetylglucosamine = 9-hydroxybenzo[a]pyrene 10-O-(N-acetylglucosaminide) + UDP
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Product in Enzyme-catalyzed Reactions (1 result)
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benzo(a)pyrene-9,10-dihydrodiol + NAD+ = 9,10-dihydroxy-benzo(a)pyrene + NADH + H+
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Enzyme Kinetic Parameters
KM Value (2 results)
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0.12
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with UDP-D-xylose, recombinant enzyme in microsomes, pH 7.4, 37°C
0.19
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with UDP-D-glucose, recombinant enzyme in microsomes, pH 7.4, 37°C
References & Links
Literature References (1)
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UDP-glycosyltransferase 3A metabolism of polycyclic aromatic hydrocarbons potential importance in aerodigestive tract tissues
2020
Vergara, A.G.; Watson, C.J.W.; Chen, G.; Lazarus, P.
Drug Metab. Dispos.
48
160-168
Links to other databases for 9,10-dihydroxy-benzo(a)pyrene