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Ligand methyl-D-erythritol-4-phosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.267

methyl-D-erythritol-4-phosphate + NADP+ = 1-deoxy-D-xylulose-5-phosphate + NADPH

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Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.267

1-deoxy-D-xylulose-5-phosphate + NADH = methyl-D-erythritol-4-phosphate + NAD+

0

-

1.1.1.267

1-deoxy-D-xylulose-5-phosphate + NADPH = methyl-D-erythritol-4-phosphate + NADP+

0

-

1.1.1.267

2 entries

Enzyme Kinetic Parameters

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.267

0.042

-

presence of Mg2+, pH 7.5, 25°C

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1.1.1.267

0.158

-

pH 7.7, presence of 3 mM MgCl2

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1.1.1.267

0.294

-

pH 7.7, presence of 1 mM MnCl2

655439

1.1.1.267

3 entries

References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

654748

15065882

Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase

2004

Argyrou, A.; Blanchard, J.S.

Biochemistry

43

4375-4384

655439

12230556

Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase

2002

Hoeffler, J.F.; Tritsch, D.; Grosdemange-Billiard, C.; Rohmer, M.

Eur. J. Biochem.

269

4446-4457

Links to other databases for methyl-D-erythritol-4-phosphate

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Show Links (1 entry)

ChEBI

PubChem

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