Ligand 2,4-dichlorophenol

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 2,4-dichlorophenol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H4ClO
2,4-dichlorophenol
HFZWRUODUSTPEG-UHFFFAOYSA-N
Synonyms:
2,4-dichlorphenol

Show all pahtways known for Show all pathways known for 2,4-dichlorophenol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,4-dichlorophenol + Cl- + H2O2 = ?
show the reaction diagram
-
2,4-dichlorophenol + O2 = ?
show the reaction diagram
-
2,4-dichlorophenol + FADH2 + O2 = 2,4-dichlorocatechol + FAD + H2O
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + pyruvate + succinate + CO2
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,4-dichlorophenol + Cl- + H2O2 = ?
show the reaction diagram
-
2,4-dichlorophenol + H2O2 + H+ = ?
show the reaction diagram
-
2,4-dichlorophenol + H2O2 = ?
show the reaction diagram
-
2,4-dichlorophenol + H2O2 = ?
show the reaction diagram
-
2,4-dichlorophenol + O2 = ?
show the reaction diagram
-
2,4-dichlorophenol + NADPH + O2 = ?
show the reaction diagram
-
2,4-dichlorphenol + O2 = chlorohydroquinone + H2O + Cl-
show the reaction diagram
-
2,4-dichlorophenol + FADH2 + O2 = 2,4-dichlorocatechol + FAD + H2O
show the reaction diagram
-
2,4-dichlorophenol + reduced acceptor = 4-chlorophenol + chloride + oxidized acceptor
show the reaction diagram
-
2,4-dichlorophenol + S-adenosyl-L-methionine = 2,3-dichloroanisole + S-adenosyl-L-homocysteine
show the reaction diagram
-
S-adenosyl-L-methionine + 2,4-dichlorophenol = S-adenosyl-L-homocysteine + 2,4-dichloro-1-methoxybenzene
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + pyruvate + succinate + CO2
show the reaction diagram
-
-
1,3-dichlorobenzene + putidaredoxin + O2 = 2,6-dichlorophenol + 2,4-dichlorophenol + 2,5-dichlorophenol + 2,3-dichlorophenol + oxidized putidaredoxin + H2O
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
75% inhibition at 1 mM
-
26.0% inhibition at 0.1 mM, 29.8% at 0.3 mM
-
above 1 mM
-
800 mM 2,4-dichlorophenol added to the CYP79B2 reconstitution assay inhibits the activity by 72%
-
IC50: 0.0007 mM, vs. 10 nM estradiol
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
6.83
-
-

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
0.24
-
pH 7.4, 30°C, inhibition of CO2 hydration activity

References & Links

Links to other databases for 2,4-dichlorophenol

ChEBI
PubChem
ChEBI
PubChem