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Ligand 8-nitroxanthine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.1.4

8-nitroxanthine + dihydrolipoic acid = 8-aminoxanthine + lipoic acid + H2O

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1.8.1.4

8-nitroxanthine + NAD(P)H = 8-aminoxanthine + NAD(P)+ + H2O

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1.8.1.4

8-nitroxanthine + NADPH = 8-aminoxanthine + NADP+ + H2O

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1.8.1.4

8-nitroxanthine + ubiquinol = 8-aminoxanthine + ubiquinone + H2O

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1.8.1.4

4 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.7.3.3

-

671971

3ld4, 3D-view

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

1.7.3.3

3ld4, 3D-view

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.7.3.3

0.0021

-

competitive inhibitor versus urate at pH 8.0

671971

References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

658431

12204577

Lipoyl dehydrogenase catalyzes reduction of nitrated DNA and protein adducts using dihydrolipoic acid or ubiquinol as the cofactor

2002

Chen, H.J.; Chen, Y.M.; Chang, C.M.

Chem. Biol. Interact.

140

199-213

671971

16114880

Procatalytic ligand strain. Ionization and perturbation of 8-nitroxanthine at the urate oxidase active site

2005

Doll, C.; Bell, A.F.; Power, N.; Tonge, P.J.; Tipton, P.A.

Biochemistry

44

11440-11446

Links to other databases for 8-nitroxanthine

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Show Links (1 entry)

ChEBI

PubChem

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