Ligand (2S)-2-isopropylmalate

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Basic Ligand Information

Molecular Structure
Picture of (2S)-2-isopropylmalate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H12O5
(2S)-2-isopropylmalate
BITYXLXUCSKTJS-ZETCQYMHSA-N
Synonyms:
(2S)-2-hydroxy-2-(propan-2-yl)butanedioic acid


Show all pahtways known for Show all BRENDA pathways known for (2S)-2-isopropylmalate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA
-
show the reaction diagram
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA
-
show the reaction diagram
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

References & Links

Links to other databases for (2S)-2-isopropylmalate

ChEBI
PubChem
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PubChem