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Ligand dihydromethanophenazine

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for dihydromethanophenazine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.98.1

coenzyme B-coenzyme M disulfide + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine

742382

-

1.8.98.1

DsrC protein disulfide + dihydromethanophenazine = DsrC protein + methanophenazine

742382

-

1.8.98.1

N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine

639394

-

1.8.98.1

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.12.98.3

H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine

440299, 440300, -

-

1.5.98.3

reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine

-

-

1.8.98.1

coenzyme B + coenzyme M + methanophenazine = N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine

-

-

1.8.98.1

coenzyme B + coenzyme M + methanophenazine = N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine

-

-

1.8.98.1

coenzyme B + coenzyme M + methanophenazine = N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine

-

-

1.8.98.1

3 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.98.1

coenzyme B-coenzyme M disulfide + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine

742382

-

1.8.98.1

DsrC protein disulfide + dihydromethanophenazine = DsrC protein + methanophenazine

742382

-

1.8.98.1

N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine = coenzyme B + coenzyme M + methanophenazine

639394

-

1.8.98.1

3 entries

Product in Enzyme-catalyzed Reactions (5 results)

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Show Product (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.12.98.3

H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine

440300, 440299, 439643, -

-

1.5.98.3

reduced coenzyme F420 + methanophenazine = oxidized coenzyme F420 + dihydromethanophenazine

-

-

1.8.98.1

coenzyme B + coenzyme M + methanophenazine = N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine

-

-

1.8.98.1

coenzyme B + coenzyme M + methanophenazine = N-(7-[(2-sulfoethyl)dithio]heptanoyl)-O3-phospho-L-threonine + dihydromethanophenazine

-

-

1.8.98.1

coenzyme B + coenzyme M + methanophenazine = N-[7-[(2-sulfoethyl)dithio]heptanoyl]-O3-phospho-L-threonine + dihydromethanophenazine

-

-

1.8.98.1

3 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.8.98.1

74

-

25°C

639394

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.8.98.1

0.092

-

25°C

639394

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

439643

10491189

Purification and catalytic properties of Ech hydrogenase from Methanosarcina barkeri

1999

Meuer, J.; Bartoschek, S.; Koch, J.; Kunkel, A.; Hedderich, R.

Eur. J. Biochem.

265

325-335

440299

9555882

Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1

1998

Abken, H.J.; Tietze, M.; Brodersen, J.; Baumer, S.; Beifuss, U.; Deppenmeier, U.

J. Bacteriol.

180

2027-2032

440300

10471795

Novel reactions involved in energy conservation by methanogenic archaea

1999

Deppenmeier, U.; Lienard, T.; Gottschalk, G.

FEBS Lett.

457

291-297

639394

11034998

Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophilo

2001

Murakami, E.; Deppenmeier, U.; Ragsdale, S.W.

J. Biol. Chem.

276

2432-2439

742382

25367508

The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough

2015

Ramos, A.R.; Grein, F.; Oliveira, G.P.; Venceslau, S.S.; Keller, K.L.; Wall, J.D.; Pereira, I.A.

Environ. Microbiol.

17

2288-2305

742382

25367508

The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough

2015

Ramos, A.R.; Grein, F.; Oliveira, G.P.; Venceslau, S.S.; Keller, K.L.; Wall, J.D.; Pereira, I.A.

Environ. Microbiol.

17

2288-2305

742382

2 entries

Links to other databases for dihydromethanophenazine

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Show Links (1 entry)