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Basic Ligand Information
Roles as Enzyme Ligand
Enzyme Kinetic Parameters
References & Links
- References
- Links

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Ligand buprenorphine

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Basic Ligand Information

Molecular Structure

Picture of buprenorphine (click for magnification)

Molecular Formula

BRENDA Name

InChIKey

C₂₉H₄₁NO₄

buprenorphine

RMRJXGBAOAMLHD-BHKLSUIZSA-N

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.17

buprenorphine + UDPglucuronate = UDP + buprenorphine O-glucuronide

488780, 488783

2.4.1.17

UDP-glucuronate + buprenorphine = UDP + buprenorphine glucuronide

676313, 658522

2.4.1.17

2 entries

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.6.1.1

a low-efficacy partial mu-opioid agonist

694258

7.6.2.2

inhibits paclitaxel transport, placental brush border membrane vesicles

711157

Enzyme Kinetic Parameters

K_i Value (2 results)

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EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

7.6.2.2

0.044

22°C, pH 7.4, inhibition of paclitaxel transport

711157

7.6.2.2

0.09

22°C, pH 7.4, inhibition of paclitaxel transport

711157

7.6.2.2

2 entries

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

488780

8806713

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1

1996

King, C.D.; Green, M.D.; Rios, G.R.; Coffman, B.L.; Owens, I.S.; Bishop, W.P.; Tephly, T.R.

Arch. Biochem. Biophys.

332

92-100

488783

9394029

Glucuronidation of opioids, carboxylic acid-containing drugs, and hydroxylated xenobiotics catalyzed by expressed monkey UDP-glucuronosyltransferase 2B9 protein

1997

Green, M.D.; Belanger, G.; Hum, D.W.; Belanger, A.; Tephly, T.R.

Drug Metab. Dispos.

1389-1394

658522

12756209

The effect of incubation conditions on the enzyme kinetics of UDP-glucuronosyltransferases

2003

Soars, M.G.; Ring, B.J.; Wrighton, S.A.

Drug Metab. Dispos.

762-767

676313

17264799

Molecular cloning of the baboon UDP-glucuronosyltransferase 1A gene family: evolution of the primate UGT1 locus and relevance for models of human drug metabolism

2007

Caspersen, C.S.; Reznik, B.; Weldy, P.L.; Abildskov, K.M.; Stark, R.I.; Garland, M.

Pharmacogenet. Genomics

11-24

694258

18285510

Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model

2008

Clark, M.J.; Linderman, J.J.; Traynor, J.R.

Mol. Pharmacol.

1538-1548

711157

19591810

Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles

2009

Hemauer, S.J.; Patrikeeva, S.L.; Nanovskaya, T.N.; Hankins, G.D.; Ahmed, M.S.

Biochem. Pharmacol.

1272-1278