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Ligand 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.43

1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl-1-pyrenebutyrate + lysophosphatidylcholine

487022, 487018

-

2.3.1.43

1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine + cholesterol = ?

663302

-

2.3.1.43

2 entries

Enzyme Kinetic Parameters

K_M Value (7 results)

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Show KM Value (7 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.43

0.00056

-

fluorescent assay, pH 7.4, 25°C, recombinant enzyme

663302

2.3.1.43

0.14

-

phospholipase activity

487022

2.3.1.43

0.19

-

phospholipase activity of recombinant enzyme expressed in baby hamster kidney cells

487022

2.3.1.43

0.55

-

phospholipase activity of recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells

487022

2.3.1.43

7.44

-

-

487022

2.3.1.43

10.1

-

recombinant enzyme expressed in baby hamster kidney cells

487022

2.3.1.43

20.5

-

recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells

487022

2.3.1.43

7 entries

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

487018

10828089

Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease

2000

Demeester, N.; Castro, G.; Desrumaux, C.; De Geitere, C.; Fruchart, J.C.; Santens, P.; Mulleners, E.; Engelborghs, S.; De Deyn, P.P.; Vandekerckhove, J.; Rosseneu, M.; Labeur, C.

J. Lipid Res.

41

963-974

487022

9555945

Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties

1998

Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.

J. Lipid Res.

39

807-820

663302

15249036

Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line

2004

Lane, S.B.; Tchedre, K.T.; Nair, M.P.; Thigpen, A.E.; Lacko, A.G.

Protein Expr. Purif.

36

157-164

Links to other databases for 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine

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Show Links (1 entry)

ChEBI

PubChem

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