Ligand Chloroacetate

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Basic Ligand Information

Molecular Structure
Picture of Chloroacetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H3ClO2
Chloroacetate
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Synonyms:
2-chloroacetate, 2-chloroacetic acid, chloroacetic acid, Monochloroacetate, monochloroacetic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
monochloroacetate + H2O = glycolate + HCl
show the reaction diagram
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monochloroacetate + H2O = 2-hydroxyacetate + chloride
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
chloroacetaldehyde + NAD+ + H2O = chloroacetate + NADH + H+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
monochloroacetate + acetoacetyl-CoA = monochloroacetyl-CoA + acetoacetate
show the reaction diagram
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monochloroacetic acid + H2O = glycolate + chloride
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (63 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta-chlorolactate + O2 = chloroacetate + CO2 + H2O
show the reaction diagram
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chloroacetaldehyde + NADP+ + H2O = chloroacetate + NADPH + H+
show the reaction diagram
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chloroacetaldehyde + NAD+ + H2O = chloroacetate + NADH + H+
show the reaction diagram
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chloroacetaldehyde + NAD+ + H2O = chloroacetate + NADH + H+
show the reaction diagram
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chloroacetaldehyde + H2O + O2 = chloroacetic acid + H2O2
show the reaction diagram
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ethyl chloroacetate + H2O = ethanol + chloroacetate
show the reaction diagram
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Nalpha-chloroacetylglycine + H2O = glycine + chloroacetate
show the reaction diagram
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2-chloroacetamide + H2O = 2-chloroacetate + NH3
show the reaction diagram
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2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-chloroacetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-D-glucose + H2O = GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNbeta(1-4)GlcNAc + chloroacetate
show the reaction diagram
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chloroacetyl L-aspartic acid + H2O = chloroacetate + L-aspartate
show the reaction diagram
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N-Chloroacetyl-D-Glu + H2O = Chloroacetate + D-Glu
show the reaction diagram
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2-chloro-N-(1-naphthyl)acetamide + H2O = chloroacetate + 1-naphthylamine
show the reaction diagram
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chloroacetonitrile + H2O = chloroacetic acid + NH3
show the reaction diagram
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chloroacetonitrile + H2O = chloroacetate + NH3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.08
-
pH 9.0, 30°C

KM Value (14 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
29
-
pH 7.5, 25°C
27.5
-
pH 7.5, D-2-haloacid dehalogenase subtype

References & Links

Links to other databases for Chloroacetate

ChEBI
PubChem
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PubChem