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Ligand 5alpha-cholesta-7,24-dien-3beta-ol

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 5alpha-cholesta-7,24-dien-3beta-ol

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.72

5alpha-cholesta-7,24-dien-3beta-ol + NADPH = 5alpha-cholest-7-en-3beta-ol + NADP+

654165, 654502, 653232

-

1.3.1.72

5alpha-cholesta-7,24-dien-3beta-ol + NADPH = 5alpha-cholesta-7-en-3beta-ol + NADP+

288496

-

1.3.1.72

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.72

5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+

0

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.72

5alpha-cholesta-7,24-dien-3beta-ol + NADPH = 5alpha-cholest-7-en-3beta-ol + NADP+

686416, 654165, 690082, 653232, 654502

-

1.3.1.72

5alpha-cholesta-7,24-dien-3beta-ol + NADPH = 5alpha-cholesta-7-en-3beta-ol + NADP+

288498, 288496

-

1.3.1.72

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.72

5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+

0

-

5.3.3.5

5alpha-cholesta-8,24-dien-3beta-ol = 5alpha-cholesta-7,24-dien-3beta-ol

0

-

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.1.72

0.037

-

-

288496

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

288496

9291139

Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol DELTA24-reductase

1997

Bae, S.H.; Paik, Y.K.

Biochem. J.

326

609-616

288498

-

Mechanistic and metabolic studies of sterol 24,25-double bond reduction in Manduca sexta

1996

Short, J.D.; Guo, D.A.; Svoboda, J.A.; Nes, W.D.

Arch. Insect Biochem. Physiol.

31

1-22

653232

9638657

Cholesterol biosynthesis from lanosterol: differential inhibition of sterol DELTA8-isomerase and other lanosterol-converting enzymes by tamoxifen

1998

Cho, S.Y.; Kim, J.H.; Paik, Y.K.

Mol. Cells

8

233-239

654165

11519011

Mutations in the 3beta-hydroxysterol DELTA24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis

2001

Waterham, H.R.; Koster, J.; Romeijn, G.J.; Hennekam, R.C.M.; Vreken, P.; Andersson, H.C.; FitzPatrick, D.R.; Kelley, R.I.; Wanders, R.J.A.

Am. J. Hum. Genet.

69

685-694

654502

12162789

Inhibition of cholesterol biosynthesis by DELTA22-unsaturated phytosterols via competitive inhibition of sterol DELTA24-reductase in mammalian cells

2002

Fernandez, C.; Suarez, Y.; Ferruelo, A.J.; Gomez-Coronado, D.; Lasuncion, M.A.

Biochem. J.

366

109-119

686416

18339707

3beta-Hydroxysteroid-DELTA24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis

2008

Lu, X.; Kambe, F.; Cao, X.; Kozaki, Y.; Kaji, T.; Ishii, T.; Seo, H.

Endocrinology

149

3267-3273

690082

18394665

Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations

2008

Pedretti, A.; Bocci, E.; Maggi, R.; Vistoli, G.

Steroids

73

708-719

Links to other databases for 5alpha-cholesta-7,24-dien-3beta-ol

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Show Links (1 entry)

ChEBI

PubChem

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