Ligand phosphonoacetaldehyde

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Basic Ligand Information

Molecular Structure
Picture of phosphonoacetaldehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H5O4P
phosphonoacetaldehyde
YEMKIGUKNDOZEG-UHFFFAOYSA-N
Synonyms:
(2-oxoethyl)phosphonate, 2-oxoethylphosphonic acid, 2-phosphonoacetaldehyde, phosphonoacetylaldehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphonoacetaldehyde + NADH + H+ = 2-hydroxyethylphosphonate + NAD+
show the reaction diagram
-
phosphonoacetaldehyde + reduced acceptor = 2-hydroxyethylphosphonate + acceptor
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine
show the reaction diagram
-
3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphonoacetaldehyde + reduced acceptor = 2-hydroxyethylphosphonate + acceptor
show the reaction diagram
-
(2-oxoethyl)phosphonate + H2O2 = ?
show the reaction diagram
-
2-phosphonoacetaldehyde + D-alanine = (2-aminoethyl)phosphonate + pyruvate
show the reaction diagram

Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-hydroxyethylphosphonate + NAD+ = phosphonoacetaldehyde + NADH + H+
show the reaction diagram
-
-
2-hydroxyethylphosphonate + NADP+ = phosphonoacetaldehyde + NADPH + H+
show the reaction diagram
-
-
pyruvate + 2-aminoethylphosphonic acid = L-alanine + 2-oxoethylphosphonic acid
show the reaction diagram
-
(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine
show the reaction diagram
3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor

3D Structure of Enzyme-Ligand-Complex (PDB) (12 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (41 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.41
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication
1.3
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication

KM Value (36 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.185
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication
0.031
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication

References & Links

Links to other databases for phosphonoacetaldehyde

ChEBI
PubChem
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PubChem