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Ligand 3-oxododecanoyl-[acyl-carrier protein]

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 3-oxododecanoyl-[acyl-carrier protein]

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.184

3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine = [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone

718655

-

2.3.1.184

3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine = N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine

701799

-

2.3.1.184

3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine = [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone

720492

-

2.3.1.184

S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein] = 5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]

666390

-

2.3.1.184

4 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.301

decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2

0

-

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.100

3-oxododecanoyl-[acyl-carrier protein] + NADPH = (R)-3-hydroxydodecanoyl-[acyl-carrier protein] + NADP+

763418, 763477

-

2.3.1.184

3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine = [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone

718655

-

2.3.1.184

3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine = N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine

701799

-

2.3.1.184

3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine = N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine

735547, 736148

-

2.3.1.184

3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine = [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone

720492

-

2.3.1.184

S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein] = 5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]

666390, 665409

-

2.3.1.184

5 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.180

decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxo-lauroyl-[acyl-carrier protein] + CoA + CO2

0

-

2.3.1.301

decanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2

0

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.100

40.9

-

pH and temperature not specified in the publication

763418

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.100

0.142

-

pH and temperature not specified in the publication

763418

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

665409

16385066

Specificity of acyl-homoserine lactone synthases examined by mass spectrometry

2006

Gould, T.A.; Herman, J.; Krank, J.; Murphy, R.C.; Churchill, M.E.

J. Bacteriol.

188

773-783

666390

15306017

Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI

2004

Gould, T.A.; Schweizer, H.P.; Churchill, M.E.

Mol. Microbiol.

53

1135-1146

701799

19525275

LasI/R and RhlI/R quorum sensing in a strain of Pseudomonas aeruginosa beneficial to plants

2009

Steindler, L.; Bertani, I.; De Sordi, L.; Schwager, S.; Eberl, L.; Venturi, V.

Appl. Environ. Microbiol.

75

5131-5140

718655

22113916

Functional characterization of the quorum sensing regulator RsaL in the plant-beneficial strain Pseudomonas putida WCS358

2012

Rampioni, G.; Bertani, I.; Pillai, C.R.; Venturi, V.; Zennaro, E.; Leoni, L.

Appl. Environ. Microbiol.

78

726-734

720492

20624221

LuxR-type quorum-sensing regulators that are detached from common scents

2010

Tsai, C.S.; Winans, S.C.

Mol. Microbiol.

77

1072-1082

735547

26245683

Involvement of quorum sensing genes in biofilm development and degradation of polycyclic aromatic hydrocarbons by a marine bacterium Pseudomonas aeruginosa N6P6

2015

Mangwani, N.; Kumari, S.; Das, S.

Appl. Microbiol. Biotechnol.

99

10283-10297

736148

25926817

Unravelling the genome of long chain N-acylhomoserine lactone-producing Acinetobacter sp. strain GG2 and identification of its quorum sensing synthase gene

2015

How, K.; Hong, K.; Sam, C.; Koh, C.; Yin, W.; Chan, K.

Front. Microbiol.

6

240

763418

29739899

Novel Xanthomonas campestris long-chain-specific 3-oxoacyl-acyl carrier protein reductase involved in diffusible signal factor synthesis

2018

Hu, Z.; Dong, H.; Ma, J.C.; Yu, Y.; Li, K.H.; Guo, Q.Q.; Zhang, C.; Zhang, W.B.; Cao, X.; Cronan, J.E.; Wang, H.

mBio

9

e00596-18

763477

31560825

A novel 3-oxoacyl-ACP reductase (FabG3) is involved in the xanthomonadin biosynthesis of Xanthomonas campestris pv. campestris

2019

Yu, Y.; Ma, J.; Guo, Q.; Ma, J.; Wang, H.

Mol. Plant Pathol.

20

1696-1709

Links to other databases for 3-oxododecanoyl-[acyl-carrier protein]

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