Ligand 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine

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Basic Ligand Information

Molecular Structure
Picture of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C42H82NO8P
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
WTJKGGKOPKCXLL-VYOBOKEXSA-O
Synonyms:
1-palmitoyl-2-oleoyl-3-sn-phosphatidylcholine, 1-palmitoyl-2-oleoyl-phosphatidylcholin, 1-palmitoyl-2-oleoyl-phosphatidylcholine, 1- palmitoyl-2-oleoyl-phosphatidylcholine, 1-palmitoyl-2-oleoylphosphatidylcholine, 1-palmitoyl-2-oleoyl phosphatidylcholine, 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine, 2-oleoyl-1-palmitoylphosphatidylcholine, palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-palmitoyl-2-oleoyl-phosphatidylcholine + H2O = 2-oleoyl-lysophosphatidylcholine + palmitic acid
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA = 1-palmitoyl-2-oleoylphosphatidylcholine + CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-palmitoyl-2-oleoyl phosphatidylcholine + NAD+ = 1-palmitoyl-2-linoleoyl phosphatidylcholine + NADH
show the reaction diagram
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1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
show the reaction diagram
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1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O = 2-oleoyl-sn-glycero-3-phosphocholine + palmitate
show the reaction diagram
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1-palmitoyl-2-oleoylphosphatidylcholine + H2O = lysophosphatidylcholine + ?
show the reaction diagram
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1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O = 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + choline
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
oleoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine = CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
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palmitoyl-CoA + 2-oleoyl-sn-glycero-3-phosphocholine = CoA + 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
in vesicles with 1,2-palmitoyl-2-oleoyl-3-sn-phosphatidylcholine, 18fold activation of enzyme activity with prothrombin
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4000
-
pH 5.0, 37°C
4000
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pH 5.0, 37°C

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.271
-
pH 5.0, 37°C
0.271
-
pH 5.0, 37°C

References & Links

Links to other databases for 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine

ChEBI
PubChem
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PubChem