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Ligand 5-sulfosalicylic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.13.1

sulfosalicylate + NADH + O2 = ? + NAD+ + H2O + CO2

675817

-

2.8.2.2

3'-phosphoadenylylsulfate + 5-sulfosalicylic acid = adenosine 3',5'-bisphosphate + 5-sulfo-2-(sulfooxy)benzoic acid

739274

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Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.10.3.1

-

699242

-

1.14.18.1

-

699242

-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.318

2.5 mM, 35% inhibition

729302

-

3.1.6.1

strong

135530

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3.5.3.18

inactivates DDAH

668175

-

4.2.1.1

competitive inhibition of isozyme carbonic anhydrase I and noncompetitive inhibition of isozyme carbonic anhydrase II

696737

-

Enzyme Kinetic Parameters

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.2.1.1

0.77

-

isozyme carbonic anhydrase I

696737

4.2.1.1

1.92

-

isozyme carbonic anhydrase II

696737

4.2.1.1

2 entries

IC₅₀ Value (2 results)

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Show IC50 Value (2 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

4.2.1.1

0.29

-

isozyme carbonic anhydrase II

696737

4.2.1.1

0.42

-

isozyme carbonic anhydrase I

696737

4.2.1.1

2 entries

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

135530

-

A phenylsulphatase from the marine brown alga Cystoseira tamariscifolia

1993

Knoess, W.; Glombitza, K.W.

Phytochemistry

32

1119-1123

668175

16897158

Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity

2006

Jiang, J.L.; Zhang, X.H.; Li, N.S.; Rang, W.Q; Feng-Ye, W.Q.; Hu, C.P.; Li, Y.J.; Deng, H.W.

Cardiovasc. Drugs Ther.

20

281-294

675817

16035243

Overexpression, purification and characterization of a new salicylate hydroxylase from naphthalene-degrading Pseudomonas sp. strain ND6

2005

Zhao, H.; Chen, D.; Li, Y.; Cai, B.

Microbiol. Res.

160

307-313

696737

18819808

In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II

2008

Bayram, E.; Senturk, M.; Kufrevioglu, O.I.; Supuran, C.T.

Bioorg. Med. Chem.

16

9101-9105

699242

18830916

Differential in vitro inhibition of polyphenoloxidase from a wild edible mushroom Lactarius salmonicolor

2009

Dedeoglu, N.; Guler, O.O.

J. Enzyme Inhib. Med. Chem.

24

464-470

729302

24412193

Purification, characterization, sequencing and molecular cloning of a novel cysteine methyltransferase that regulates trehalose-6-phosphate synthase from Saccharomyces cerevisiae

2014

Sengupta, S.; Banerjee, S.; Lahiri, S.; Dutta, T.; Dhar, T.K.; Ghosh, A.K.

Biochim. Biophys. Acta

1840

1861-1871

739274

25736839

Detoxification function of the Arabidopsis sulphotransferase AtSOT12 by sulphonation of xenobiotics

2015

Chen, J.; Gao, L.; Baek, D.; Liu, C.; Ruan, Y.; Shi, H.

Plant Cell Environ.

38

1673-1682

Links to other databases for 5-sulfosalicylic acid

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Show Links (1 entry)

ChEBI

PubChem