Ligand ribavirin

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Basic Ligand Information

Molecular Structure
Picture of ribavirin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H12N4O5
ribavirin
IWUCXVSUMQZMFG-AFCXAGJDSA-N
Synonyms:
1,2,4,triazole-3-carboxamide riboside, 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, RBV

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
viramidine + H2O = ribavirin + NH3
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ribavirin + O2 = 1-(beta-D-ribofuranuronosyl)-1H-1,2,4-triazole-3-carboxamide + H2O2
show the reaction diagram
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ATP + ribavirin = ADP + ribavirin 5'-phosphate
show the reaction diagram
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ATP + ribavirin = ADP + ribavirin monophosphate
show the reaction diagram
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ATP + ribavirin = ?
show the reaction diagram
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ATP + ribavirin = ADP + ribavirin 5'-phosphate
show the reaction diagram
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3 ribavirin = ?
show the reaction diagram
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ribavirin + 5'-IMP = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate = ribavirin + phosphate
show the reaction diagram
-
-
viramidine + H2O = ribavirin + NH3
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 10% increased activity at 0.1 mM
-
activates ATPase activity, no effect on helicase activity
-

Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 10% inhibition at 0.1 mM
-
deoxyadenosine as substrate
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prolonged treatment of erythrocytes with ribavirin results in surface exposure of phosphatidylserine, mainly caused by inactivation of the aminophospholipid translocase. Inactivation is due to severe ATP depletion
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.2
-
pH 7.5, 37°C
0.79
-
pH 7.0, 37°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.5
-
pH 7.5, 37°C, substrate deoxyadenosine

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1.18
-
at pH 7.3 and 25°C

References & Links

Links to other databases for ribavirin

ChEBI
PubChem
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PubChem