Ligand deamido-NAD+

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Basic Ligand Information

Molecular Structure
Picture of deamido-NAD+ (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H26N6O15P2
deamido-NAD+
SENPVEZBRZQVST-HISDBWNOSA-O
Synonyms:
deamino-NAD+, nicotinate adenine dinucleotide, nicotinic acid-adenine dinucleotide, nicotinic acid adenine dinucleotide, oxidized acetyl pyridine adenine dinucleotide


Show all pahtways known for Show all BRENDA pathways known for deamido-NAD+

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

In Vivo Product in Enzyme-catalyzed Reactions (37 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (106 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-malate + deamino-NAD+ = oxaloacetate + deamino-NADH + H+
show the reaction diagram
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formate + deamino-NAD+ = CO2 + deamino-NADH
show the reaction diagram
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propanal + deamino-NAD+ + H2O = propionate + deamino-NADH
show the reaction diagram
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acetaldehyde + deamino-NAD+ + H2O = acetate + deamino-NADH + H+
show the reaction diagram
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L-Ala + H2O + deamino-NAD+ = pyruvate + NH3 + deamino-NADH
show the reaction diagram
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L-glutamate + deamino-NAD+ = L-glutamine + 2-oxoglutarate + deamino-NADH + H+
show the reaction diagram
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L-lysine + deamino-NAD+ + H2O = alpha-aminoadipate delta-semialdehyde + NH3 + deamino-NADH
show the reaction diagram
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L-phenylalanine + H2O + deamino-NAD+ = phenylpyruvate + NH3 + deamino-NADH
show the reaction diagram
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L-Leu + H2O + deamino-NAD+ = 4-methyl-2-oxopentanoate + NH3 + deamino-NADH
show the reaction diagram
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L-erythro-3,5-diaminohexanoate + H2O + deamino-NAD+ = 5-amino-3-oxohexanoate + NH3 + deamino-NADH + H+
show the reaction diagram
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NADPH + deamino-NAD+ = NADP+ + deamino-NADH
show the reaction diagram
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NADPH + deamino-NAD+ = NADP+ + deamino-NADH
show the reaction diagram
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deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide
show the reaction diagram
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phosphate + deamino-NAD+ = ?
show the reaction diagram
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deamino-NAD+ + H2O = ?
show the reaction diagram
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nicotinic acid adenine dinucleotide + H2O = ?
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deamino-NAD+ + H2O = deamino-NMN + AMP
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nicotinic acid adenine dinucleotide + H2O = nicotinic acid mononucleotide + 5'-AMP
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Product in Enzyme-catalyzed Reactions (63 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
deamino-NADH + H+ + 2,3-dimethoxy-5-methyl-1,4-benzoquinone = deamino-NAD+ + 2,3-dimethoxy-5-methyl-1,4-benzoquinol
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (21 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
2fold activity compared to NAD+
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reduced at nearly the same rate as NAD+
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86% of the activity with NAD+ in the reaction with L-Phe
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Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive versus NAD+ and noncompetitive versus L-lactate
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product inhibition
5 mM, almost complete inhibition
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0.02 mM, 96% residual activity in presence of 0.05 mM NAD, pH 7.4
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product inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (104 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (42 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.264
-
-
0.54
-
-
0.326
-
-
1.85
-
-
0.18
-
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22
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pH 8.8
0.4
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cosubstrate NADPH
0.013
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pH 8.0, 22°C
2.6
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in presence of 20 mM MgCl2, 50 mM Tris-HCl, pH 8.5
0.008
-
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References & Links

Links to other databases for deamido-NAD+

ChEBI
PubChem
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PubChem