Ligand dioleoyl phosphatidic acid

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Basic Ligand Information

Molecular Structure
Picture of dioleoyl phosphatidic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C39H73O8P
dioleoyl phosphatidic acid
MHUWZNTUIIFHAS-CLFAGFIQSA-N
Synonyms:
1,2-di-O-oleoyl-rac-glycero-3-phosphate, 1,2-dioleoyl-sn-glycero-3-phosphate, 2,3-di-O-oleoyl-sn-glycero-1-phosphate, dioleoylglycerol 3-phosphate, dioleoylphosphatidic acid, rac-1,2-dioleoylglycerol 3-phosphate, sn-1,2-dioleoylglycerol 3-phosphate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-dioleoyl-sn-glycero-3-phosphate + H2O = 1,2-dioleoyl-sn-glycerol + phosphate
show the reaction diagram
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dioleoyl phosphatidic acid + H2O = 1,2-dioleoyl-sn-glycerol + phosphate
show the reaction diagram
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dioleoylphosphatidic acid + H2O = 1,2-dioleoylglycerol + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-dioleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O = 1,2-dioleoyl-sn-glycero-3-phosphate + N-palmitoyl-phosphatidylethanolamine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
very strong activation
-
stimulates about 10fold
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. DOPA, negatively charged phospholipid, strongly inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
24
-
pH and temperature not specified in the publication

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.3
-
pH and temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0002
-
cytosolic isozyme, pH 7.2, 25°C

References & Links

Links to other databases for dioleoyl phosphatidic acid

ChEBI
PubChem
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PubChem