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Ligand dioleoyl phosphatidic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.7.41

CTP + 1,2-dioleoyl-sn-glycero-3-phosphate = diphosphate + CDP-1,2-dioleoylglycerol

762488

-

3.1.3.27

1,2-dioleoyl-sn-glycero-3-phosphate + H2O = 1,2-dioleoyl-sn-glycerol + phosphate

730834

-

3.1.3.4

dioleoyl phosphatidic acid + H2O = 1,2-dioleoyl-sn-glycerol + phosphate

134897, 134896

-

3.1.3.51

dioleoylphosphatidic acid + H2O = 1,2-dioleoylglycerol + phosphate

134922

-

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.51

oleoyl-CoA + 1-oleoyl-2-lysophosphatidylglycerol = CoA + 1,2-dioleoyl-sn-glycero-3-phosphate

-

-

2.3.1.51

oleoyl-ACP + sn-1-oleoylglycerol 3-phosphate = ACP + sn-1,2-dioleoylglycerol 3-phosphate

487203

-

2.7.1.107

GTP + dioleoylglycerol = GDP + dioleoylglycerol 3-phosphate

-

-

2.7.1.107

ATP + rac-1,2-dioleoylglycerol = ADP + rac-1,2-dioleoylglycerol 3-phosphate

-

-

2.7.1.107

ATP + sn-1,2-dioleoylglycerol = ADP + sn-1,2-dioleoylglycerol 3-phosphate

-

-

2.3.1.51

2 entries

2.7.1.107

3 entries

3.1.4.54

1,2-dioleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O = 1,2-dioleoyl-sn-glycero-3-phosphate + N-palmitoyl-phosphatidylethanolamine

-

-

Activator in Enzyme-catalyzed Reactions (2 results)

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Show Activating Compound (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.15

very strong activation

486392

-

2.4.1.212

stimulates about 10fold

674706

-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.2.6

i.e. DOPA, negatively charged phospholipid, strongly inhibits the cytosolic isozyme noncompetitively, specific ionic and probably also hydrophobic interaction

653833

-

3.4.21.39

-

29374

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.3.27

24

-

pH and temperature not specified in the publication

730834

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.3.27

0.3

-

pH and temperature not specified in the publication

730834

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.2.6

0.0002

-

cytosolic isozyme, pH 7.2, 25°C

653833

References & Links

Literature References (11)

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Show Reference (11 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

29374

3890754

Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions

1985

Kido, H.; Fukusen, N.; Katunuma, N.

Arch. Biochem. Biophys.

239

436-443

134896

8948459

Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

1995

Fleming, I.N.; Yeaman, S.J.

Biochem. J.

308

983-989

134897

-

Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase

1997

English, D.; Martin, M.; Harvea, K.A.; Akard, L.P.; Allen, R.; Widlanski, T.S.; Garcia, J.G.; Siddiqui, R.A.

Biochem. J.

324

941-950

134922

9565603

Purification and characterization of a polyisoprenyl phosphate phosphatase from pig brain

1998

Frank, D.W.; Waechter, C.J.

J. Biol. Chem.

273

11791-11798

486392

11284717

Purification and characterization of thiol-reagent-sensitive glycerol-3-phosphate acyltransferase from the membrane fraction of an oleaginous fungus

2001

Mishra, S.; Kamisaka, Y.

Biochem. J.

355

315-322

487203

-

sn-1-Acylglycerol-3-phosphate acyltransferase of Escherichia coli causes insertion of cis-11 eicosenoic acid into the sn-2 position of transgenic rapeseed oil

1998

Weier, D.; Luhs, W.; Dettendorfer, J.; Frentzen, M.

Mol. Breed.

4

39-46

653833

10944391

Specific interaction of cytosolic and mitochondrial glyoxalase II with acidic phospholipids in form of liposomes results in the inhibition of the cytosolic enzyme only

2000

Scire, A.; Tanfani, F.; Saccucci, F.; Bertoli, E.; Principato, G.

Proteins

41

33-39

674706

16984914

Phospholipid dependence and liposome reconstitution of purified hyaluronan synthase

2006

Weigel, P.H.; Kyossev, Z.; Torres, L.C.

J. Biol. Chem.

281

36542-36551

730834

24821770

Crystal structure of lipid phosphatase Escherichia coli phosphatidylglycerophosphate phosphatase B

2014

Fan, J.; Jiang, D.; Zhao, Y.; Liu, J.; Zhang, X.C.

Proc. Natl. Acad. Sci. USA

111

7636-7640

762488

31178220

Structures of the mitochondrial CDP-DAG synthase Tam41 suggest a potential lipid substrate pathway from membrane to the active site

2019

Jiao, H.; Yin, Y.; Liu, Z.

Structure

27

1258-1269

762488

31178220

Structures of the mitochondrial CDP-DAG synthase Tam41 suggest a potential lipid substrate pathway from membrane to the active site

2019

Jiao, H.; Yin, Y.; Liu, Z.

Structure

27

1258-1269

762488

2 entries

Links to other databases for dioleoyl phosphatidic acid

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Show Links (1 entry)