Ligand COS

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Basic Ligand Information

Molecular Structure
Picture of COS (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
COS
COS
JJWKPURADFRFRB-UHFFFAOYSA-N
Synonyms:
(1b) carbonyl sulfide, carbonyl sulfide, carbonylsulfide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbonyl sulfide + H2O = CO2 + H2S
show the reaction diagram
-
carbonyl sulfide + H2O = hydrogen sulfide + CO2
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbonyl sulfide + H2O = hydrogen sulfide + CO2
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
carbonyl disulfide + H2O = carbonyl sulfide + CO2
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
in presence of HCO3-, noncompetitive and irreversible, not at CO2-binding site
-
rapid-equilibrium inhibitor largely competitive versus CO, uncompetitive versus methyl viologen
-
3 mM, slightly inhibitory
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1800
-
pH and temperature not specified in the publication
58
-
at pH 8.5 and 30°C
41
-
pH 8-9, 25°C

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.86
-
pH 8-9, 25°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for COS

ChEBI
PubChem
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PubChem