Ligand Cyanovaleramide
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Basic Ligand Information
Molecular Structure
C6H10N2O
Cyanovaleramide
XZUDGZXKOFPLBC-UHFFFAOYSA-N
5-cyanovaleramide, Cyano-5-valeramide
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (4 results)
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cyano-5-valeramide + H2O = valeramide + NH3
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cyano-5-valeramide + H2O = glutaric acid 5-amide + NH3
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5-cyanovaleramide = adiponitrile + H2O
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cyanovaleramide = valerodinitrile + H2O
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Product in Enzyme-catalyzed Reactions (1 result)
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adiponitrile + H2O = 5-cyanovaleramide
-
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (3 results)
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19.6
-
pH 7.4, 35°C, mutant enzyme Y68T
21.3
-
pH 7.4, 35°C, mutant enzyme W72Y
435.7
-
pH 7.4, 35°C, wild-type enzyme
KM Value (5 results)
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13.2
-
pH 7.4, 35°C, wild-type enzyme
113.2
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pH 7.4, 35°C, mutant enzyme W72Y
127.6
-
pH 7.4, 35°C, mutant enzyme Y68T
Ki Value (2 results)
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References & Links
Literature References (3)
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Aliphatic nitrilase from a soil-isolated Comamonas testosteroni sp.: gene cloning and overexpression, purification and primary structure
1995
Levy-Schil, S.; Soubrier, F.; Crutz-Le Coq, A.M.; Faucher, D.; Crouzet, J.; Petre, D.
Gene
161
15-20
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Purification and characterization of nitrile hydratase of a mutant strain of Brevibacterium sp.
1993
Moreau, J.L.; Azza, S.; Arnaud, A.; Galzy, P.
J. Basic Microbiol.
33
323-329
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Modulation of nitrile hydratase regioselectivity towards dinitriles by tailoring the substrate binding pocket residues
2018
Cheng, Z.; Cui, W.; Xia, Y.; Peplowski, L.; Kobayashi, M.; Zhou, Z.
ChemCatChem
10
449-458
Links to other databases for Cyanovaleramide
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