Ligand pyridoxamine

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Basic Ligand Information

Molecular Structure
Picture of pyridoxamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H12N2O2
pyridoxamine
NHZMQXZHNVQTQA-UHFFFAOYSA-N

Show all pahtways known for Show all pathways known for pyridoxamine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridoxamine + pyruvate = pyridoxal + L-alanine
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pyridoxamine + oxaloacetate = pyridoxal + L-aspartate
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Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridoxamine + acceptor = 4-aminomethyl-5-formyl-2-methylpyridin-3-ol + reduced acceptor
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UDPglucose + pyridoxamine = UDP + 5'-O-beta-D-glucosylpyridoxamine
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pyridoxamine + oxaloacetate = pyridoxal + L-aspartate
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pyridoxamine + 2-oxoglutarate = pyridoxal + D-glutamate
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ATP + pyridoxamine = ADP + pyridoxamine 5'-phosphate
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridoxal + L-alanine = pyridoxamine + pyruvate
show the reaction diagram
-
pyridoxamine 5'-phosphate + H2O = pyridoxamine + phosphate
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-
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pyridoxamine 5'-phosphate + H2O = pyridoxamine + phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
approx. 0.1 mM, 22% inhibition of isozyme A
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weak inhibition of phosphorylase I, not II
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competitive inhibitor of pyridoxine glucosylation
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (10 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (20 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.26
-
-
2.4
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pH 6.2, 37°C

References & Links

Links to other databases for pyridoxamine

ChEBI
PubChem
ChEBI
PubChem