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Ligand N6-acetyl-N6-hydroxy-L-lysine

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for N6-acetyl-N6-hydroxy-L-lysine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.38

2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

720473, 492296, 486099, 719001, 719292

-

6.3.2.39

2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

719292

-

6.3.2.39

2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + aerobactin

720473, 492296, 486099, 719001

-

6.3.2.39

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.102

acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine

486099

-

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.38

2 alpha,beta-methylene-ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 alpha,beta-methylene-ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

492296

-

6.3.2.38

2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

719292, 720473, 492296, 486099, 719001

-

6.3.2.39

2 ATP + citrate + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine

719292

-

6.3.2.39

2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O = 2 ADP + 2 phosphate + aerobactin

720473, 492296, 486099, 719001

-

6.3.2.38

2 entries

6.3.2.39

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.102

acetyl-CoA + DL-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine

0

-

2.3.1.102

acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine

486099, 486098

-

2.3.1.102

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

486098

3521734

Isolation and properties of N epsilon-hydroxylysine:acetyl coenzyme A nepsilon-transacetylase from Escherichia coli pABN11

1986

Coy, M.; Paw, B.H.; Bindereif, A.; Neilands, J.B.

Biochemistry

25

2485-2489

486099

2935523

Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12

1986

Lorenzo de, V.; Bindereif, A.; Paw, B.H.; Neilands, J.B.

J. Bacteriol.

165

570-578

492296

-

Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1

1984

Appanna, D.L.; Grundy, B.J.; Szczepan, E.W.; Viswanatha, T.

Biochim. Biophys. Acta

801

437-443

719001

4313071

The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I

1969

Gibson, F.; Magrath, D.I.

Biochim. Biophys. Acta

192

175-184

719292

15719346

A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases

2005

Challis, G.L.

ChemBioChem

6

601-611

720473

3003525

Identification of the genes and their polypeptide products responsible for aerobactin synthesis by pColV plasmids

1985

Gross, R.; Engelbrecht, F.; Braun, V.

Mol. Gen. Genet.

201

204-212

Links to other databases for N6-acetyl-N6-hydroxy-L-lysine

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Show Links (1 entry)

ChEBI

PubChem