Ligand N,N-dimethyltryptamine
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Basic Ligand Information
C12H16N2
N,N-dimethyltryptamine
DMULVCHRPCFFGV-UHFFFAOYSA-N
alpha,alpha-N,N-dimethyltryptamine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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N,N-dimethyltryptamine + reduced acceptor + O2 = psilocin + acceptor + H2O
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Substrate in Enzyme-catalyzed Reactions (1 result)
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N,N-dimethyltryptamine + reduced acceptor + O2 = psilocin + acceptor + H2O
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Product in Enzyme-catalyzed Reactions (3 results)
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2 S-adenosyl-L-methionine + tryptamine = 2 S-adenosyl-L-homocysteine + N,N-dimethyltryptamine
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S-adenosyl-L-methionine + alpha-N-methyltryptamine = S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine
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S-adenosyl-L-methionine + N-methyltryptamine = S-adenosyl-L-homocysteine + N,N-dimethyltryptamine
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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Enzyme Kinetic Parameters
Ki Value (2 results)
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0.006
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N-methyltransferase B
0.01
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N-methyltransferase A
References & Links
Literature References (6)
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Partial purification and some properties of tryptophan decarboxylase from Phalaris tuberosa
1972
Baxter, C.; Slaytor, M.
Phytochemistry
11
2763-2766
Rat brain de-acetylating activity: stereospecific inhibition by LSD and serotonin-related compounds
1976
Paul, S.M.; Halaris, A.E.
Biochem. Biophys. Res. Commun.
70
207-211
Reevaluation of the products of tryptamine catalyzed by rabbit liver N-methyltransferases
1986
Crooks, P.A.; Godin, C.S.; Nwosu, C.G.; Ansher, S.S.; Jakoby, W.B.
Biochem. Pharmacol.
35
1600-1603
Multiple N-methyltransferases for aromatic alkylamines in brain
1973
Hsu, L.L.; Mandell, A.J.
Life Sci.
13
847-858
Amine N-methyltransferases from rabbit liver
1986
Ansher, S.S.; Jakoby, W.B.
J. Biol. Chem.
261
3996-4001
Enzymatic synthesis of psilocybin
2017
Fricke, J.; Blei, F.; Hoffmeister, D.
Angew. Chem. Int. Ed. Engl.
56
12352-12355
Links to other databases for N,N-dimethyltryptamine