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Ligand quercetin 7-O-glucoside

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.21

quercetin 7-O-beta-D-glucopyranoside + H2O = quercetin + beta-D-glucose

654522

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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.237

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

-

-

2.4.1.237

UDP-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

-

-

2.4.1.237

2 entries

Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Substrate (5 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.115

quercetin 7-O-glucoside + malonyl-CoA = CoA + quercetin 7-O-glucoside 6''-O-malonylester

486145

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2.4.1.234

UDP-D-galactose + quercetin 7-O-glucoside = UDP + quercetin 7-O-glucoside-3-O-beta-D-galactoside

489559

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2.4.1.91

UDP-alpha-D-glucose + quercetin 7-O-beta-D-glucoside = UDP + quercetin 3,7-O-di-beta-D-glucoside

489559, 489566

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2.4.1.B53

UDP-L-rhamnose + quercetin 7-O-beta-D-glucoside = UDP + quercetin 7-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]

723433, 737014

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3.2.1.21

quercetin 7-O-beta-D-glucopyranoside + H2O = quercetin + beta-D-glucose

654522, 655434, 681442

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Product in Enzyme-catalyzed Reactions (11 results)

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Show Product (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.104

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

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-

2.4.1.111

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

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-

2.4.1.170

UDP-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

-

-

2.4.1.185

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

488819, 488817

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2.4.1.185

UDP-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

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-

2.4.1.237

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

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-

2.4.1.237

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside + quercetin 3-O-beta-D-glucoside

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-

2.4.1.237

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside + quercetin 4'-O-beta-D-glucoside

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-

2.4.1.237

UDP-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

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-

2.4.1.185

2 entries

2.4.1.237

4 entries

2.4.1.35

UDP-alpha-D-glucose + quercetin = UDP + quercetin 3'-O-beta-D-glucoside + quercetin 7-O-beta-D-glucoside + quercetin 7,3'-di-O-beta-D-glucoside

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-

2.4.1.81

UDP-alpha-D-glucose + quercetin = UDP + quercetin 7-O-beta-D-glucoside

-

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (3 results)

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Show Turnover Number (3 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.2.1.21

0.6

-

recombinant wild-type enzyme

681442

3.2.1.21

0.69

-

37°C, pH 6.5

655434

3.2.1.21

0.69

-

50°C, pH 6.5

654522

3.2.1.21

3 entries

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.115

0.381

-

-

486145

3.2.1.21

0.042

-

37°C, pH 6.5

655434

3.2.1.21

36.1

-

recombinant wild-type enzyme

681442

3.2.1.21

42.2

-

50°C, pH 6.5

654522

3.2.1.21

3 entries

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

486145

6497385

Malonyl-coenzyme A:isoflavone 7-O-glucoside-6-O-malonyltransferase from roots of chick pea (Cicer arietinum L.)

1984

Koester, J.; Bussmann, R.; Barz, W.

Arch. Biochem. Biophys.

234

513-521

488817

-

Biosynthesis of naringin in Citrus paradisi: UDP-glucosyl-transferase activity in grapefruit seedlings

1990

McIntosh, C.A.; Mansell R.L.

Phytochemistry

29

1533-1538

488819

10626374

Flavanone-7-O-glucosyltransferase activity from Petunia hybrida

1999

Durren, R.L.; McIntosh, C.A.

Phytochemistry

52

793-798

489559

-

Partial purification and some properties of flavonol 3-O-glycosyltransferases from seedlings of Vigna mungo, with special reference to the formation of kaempferol 3-O-galactoside and 3-O-glucoside

1993

Ishikura, N.; Mato, M.

Plant Cell Physiol.

34

329-335

489566

-

Multiple forms of flavonol O-glucosyltransferases in young leaves of Euonymus alatus f. ciliato-denatus

1994

Ishikura, N.; Yang, Z.Q.

Phytochemistry

36

1139-1145

654522

12667141

Substrate (aglycone) specificity of human cytosolic beta-glucosidase

2003

Berrin, J.G.; Czjzek, M.; Kroon, P.A.; McLauchlan, W.R.; Puigserver, A.; Williamson, G.; Juge, N.

Biochem. J.

373

41-48

655434

11784319

Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides

2002

Berrin, J.G.; McLauchlan, W.R.; Needs, P.; Williamson, G.; Puigserver, A.; Kroon, P.A.; Juge, N.

Eur. J. Biochem.

269

249-258

681442

17555766

The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase

2007

Tribolo, S.; Berrin, J.G.; Kroon, P.A.; Czjzek, M.; Juge, N.

J. Mol. Biol.

370

964-975

723433

22989156

The molecular and enzymatic basis of bitter/non-bitter flavor of citrus fruit: evolution of branch-forming rhamnosyltransferases under domestication

2013

Frydman, A.; Liberman, R.; Huhman, D.V.; Carmeli-Weissberg, M.; Sapir-Mir, M.; Ophir, R.; W Sumner, L.; Eyal, Y.

Plant J.

73

166-178

737014

24072327

Linkage mapping, molecular cloning and functional analysis of soybean gene Fg2 encoding flavonol 3-O-glucoside (1->6) rhamnosyltransferase

2014

Rojas Rodas, F.; Rodriguez, T.; Murai, Y.; Iwashina, T.; Sugawara, S.; Suzuki, M.; Nakabayashi, R.; Yonekura-Sakakibara, K.; Saito, K.; Kitajima, J.; Toda, K.; Takahashi, R.

Plant Mol. Biol.

84

287-300

Links to other databases for quercetin 7-O-glucoside

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Show Links (1 entry)

ChEBI

PubChem

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