Ligand pregnenolone sulfate

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Basic Ligand Information

Molecular Structure
Picture of pregnenolone sulfate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H32O5S
pregnenolone sulfate
DIJBBUIOWGGQOP-QGVNFLHTSA-M
Synonyms:
3beta-Hydroxypregn-5-en-20-one sulfate, pregnenolone 3-sulfate
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cholesterol sulfate + reduced adrenodoxin + O2 = pregnenolone sulfate + 17-hydroxy-pregnenolone + dehydroisoandrosterone sulfate + oxidized adrenodoxin + H2O
show the reaction diagram
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3'-phosphoadenylylsulfate + pregnenolone = adenosine 3',5'-bisphosphate + pregnenolone 3-sulfate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3)
-
competitive inhibitor, dehydroepiandrosterone 3-sulfate as substrate
-

Enzyme Kinetic Parameters

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0025
-
isoform PanK3, at pH 7.5 and 37C

References & Links

Links to other databases for pregnenolone sulfate

ChEBI
PubChem
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PubChem