Ligand (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
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Basic Ligand Information
Molecular Structure

C20H32O4
(5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
QQUFCXFFOZDXLA-VYOQERLCSA-M
(5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate, (8S)-HPETE, 8(S)-HPETE
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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(8S)-HPETE = (10R)-hydroxy-(8S,9S)-epoxyeicosa-(5Z,11Z,14Z)-trienoic acid + H2O
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)
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arachidonate + O2 = (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
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arachidonate + O2 = (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
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Substrate in Enzyme-catalyzed Reactions (2 results)
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(8S)-HPETE = (10R)-hydroxy-(8S,9S)-epoxyeicosa-(5Z,11Z,14Z)-trienoic acid + H2O
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(8S)-HPETE = (10R)-hydroxy-(8S,9S)-epoxyeicosa-(5Z,11Z,14Z)-trienoic acid
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Product in Enzyme-catalyzed Reactions (2 results)
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arachidonate + O2 = (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate
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arachidonate + O2 = (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
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Enzyme Kinetic Parameters
References & Links
Literature References (1)
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Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin
2006
Yu, Z.; Schneider, C.; Boeglin, W.E.; Brash, A.R.
Arch. Biochem. Biophys.
455
188-196
Links to other databases for (5Z,9E,11Z,14Z)-(8S)-8-hydroperoxyeicosa-5,9,11,14-tetraenoate