Ligand Substance P

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Basic Ligand Information

Molecular Structure
Picture of Substance P (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C63H97N17O14S
Substance P
XHWDVRRNQHMAPE-CUZNLEPHSA-N
Synonyms:
RPKPQQFFGLM, substance P(free acid)

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
substance P + ascorbate + O2 = ? + dehydroascorbate + H2O
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (42 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
substance P + ascorbate + O2 = ? + dehydroascorbate + H2O
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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RPKPQQFFGLM + H2O = RPKPQ + QFF + GLM
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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substance P + H2O = RPKPQQFF + Gly-Leu-Met
show the reaction diagram
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Substance P + H2O = Arg-Pro-Lys-Pro-Gln-Gln-Phe + Phe-Gly-Leu-Met-NH2
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
-
Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
-
Substance P + H2O = ?
show the reaction diagram
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Substance P + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Leu + Met = substance P
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induces granzyme B expression in mast cell line LAD2 and cord blood-derived mast cells
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Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
human peptide hormone, 100 microM, Arg 4-methylcoumarin 7-amide hydrolysis: 63.8% (wild-type enzyme); human peptide hormone, 10 microM, Arg 4-methylcoumarin 7-amide hydrolysis: 78% (wild-type enzyme)
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.1
-
pH 8.2, 37°C, recombinant wild-type enzyme
160
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pH 8.6, 30°C
0.63
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pH 8.0, 37°C

KM Value (20 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.077
-
pH 8.2, 37°C, recombinant wild-type enzyme
0.025
-
-
0.031
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pH 8.0, 37°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00044
-
-
0.19
-
hydrolysis of Leu5-enkephalin
0.011
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37°C, pH 7.2, wild-type enzyme

References & Links

Links to other databases for Substance P

ChEBI
PubChem
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PubChem